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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Foyet, Harquin Simplice Hritcu, Lucian Ciobica, Alin Stefan, Marius Kamtchouing, Pierre Cojocaru, Dumitru |
| Description | Country affiliation: Cameroon Author Affiliation: Foyet HS ( Department of Agriculture, Cattle farming and Derived products, High Institute of the Sahel, University of Maroua, Cameroon.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: While the Hibiscus asper Hook.f. (Malvaceae) is a traditional herb largely used in tropical region of the Africa as vegetable, potent sedative, tonic and restorative, anti-inflammatory and antidepressive drug, there is very little scientific data concerning the efficacy of this. AIM OF THE STUDY: We investigated antioxidant activity and the effects of methanolic extract of Hibiscus asper leaves on neurological capacity of male Wistar rats subjected to unilateral 6-hydroxydopamine (6-OHDA)-lesion. MATERIALS AND METHODS: Two model systems: 2,4-dinitrophenyl-1-picryl hydrazyl (DPPH) radical scavenging activity and ß-carotene bleaching inhibition assay were used to measure the antioxidant activities of the plan extract. We also investigated the neuroprotective effect of methanolic extract of Hibiscus asper leaves (50 and 100 mg/kg) in male Wistar rats subjected to unilateral 6-hydroxydopamine (6-OHDA)-lesion rat model. RESULTS: Methanolic extract of Hibiscus asper leaves showed potent antioxidant and free radical scavenging activity. Chronic administration of methanolic extract (50 and 100 mg/kg, i.p., daily, for 7 days) significantly reduce anxiety-like behavior and inhibit depression in elevated plus-maze and forced swimming tests, suggesting anxiolytic and antidepressant activity. Also, spatial memory performance in Y-maze and radial arm-maze tasks was improved, suggesting positive effects on memory formation. CONCLUSIONS: Taken together, our results suggest that the methanolic extract of Hibiscus asper leaves have antioxidant effects and might provide an opportunity to management neurological abnormalities in Parkinson's disease conditions. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 133 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-27 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Hibiscus Memory Disorders Drug Therapy Neuroprotective Agents Pharmacology Parkinsonian Disorders Animals Antioxidants Administration & Dosage Isolation & Purification Ethnopharmacology Chemistry Male Maze Learning Drug Effects Medicine, African Traditional Physiopathology Psychology Methanol Oxidopamine Toxicity Phytotherapy Plant Extracts Plant Leaves Plants, Medicinal Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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