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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Joo Youn Jeong, Ha Yeon Lee, Hong Kyu Yoo, Jae Kuk Bae, Kihwan Seong, Yeon Hee |
| Description | Country affiliation: South Korea Author Affiliation: Kim JY ( College of Veterinary Medicine, Chungbuk National University, 410, Sungbong-ro, Heungduk-gu, Cheongju, Chungbuk 361-763, South Korea.) |
| Abstract | AIMS OF THE STUDY: Ilex latifolia (Aquifoliaceae), a primary component of 'kudingcha', has been used in Chinese folk medicine to treat various kinds of diseases including headaches, inflammatory diseases, and cardiac ischemic injury. The present study investigated the protective effect of the ethanol extract of Ilex latifolia against transient, focal, ischemia-induced neuronal damage. MATERIALS AND METHODS: Transient focal ischemia was induced by 2 h middle cerebral artery occlusion followed by 24 h reperfusion (MCAO/reperfusion) in rats. After MCAO/reperfusion, brain infarction and neuronal death were measured by triphenyltetrazolium chloride and hematoxylin and eosin staining, respectively. Glutathione concentration and lipid peroxidation rate were measured. The expression levels of phosphorylated mitogen activated proteins kinases (MAPKs), cyclooxygenase 2 (COX-2), and anti-apoptotic and pro-apoptotic proteins were detected by Western blot. RESULTS: Ilex latifolia (50-200 mg/kg) significantly reduced MCAO/reperfusion-induced infarction and edema formation, neurological deficits, and brain cell death. Depletion of glutathione level and lipid peroxidation induced by MCAO/reperfusion were inhibited by administration of Ilex latifolia. The increase of phosphorylated MAPKs, COX-2, and proapoptotic proteins and the decrease of antiapoptotic protein in MCAO/reperfusion rats were significantly inhibited by treatment with Ilex latifolia. CONCLUSION: Ilex latifolia ameliorated ischemic injury induced by MCAO/reperfusion in rats, and this neuroprotective effect might be associated with its anti-apoptotic effect, resulting from anti-oxidative and anti-inflammatory actions. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 133 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-27 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Brain Ischemia Drug Therapy Ilex Neuroprotective Agents Pharmacology Phytotherapy Animals Behavior, Animal Drug Effects Pathology Physiopathology Cyclooxygenase 2 Metabolism Drugs, Chinese Herbal Ethnopharmacology Glutathione Humans Chemistry Lipid Peroxidation Map Kinase Signaling System Male Medicine, Chinese Traditional Neurons Rats Rats, Sprague-dawley Reperfusion Injury Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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