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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kasabri, Violet Afifi, Fatma U. Hamdan, Imad |
| Spatial Coverage | Jordan |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Achillea santolina L., Pistacia atlantica Desf, Rheum ribes L., Sarcopoterium spinosum (L.) Spach and Teucrium polium L. have traditionally been used as herbal antidiabetic medicines. However their alleged benefits and mechanisms remain elusive. AIM OF THE STUDY: This study aimed to evaluate the effect of water extracts of these plants in in vitro and in vivo experiments. MATERIALS AND METHODS: In vitro enzymatic starch digestion with aqueous extracts from plants at concentrations of 1, 5, 10, 12.5, 25, 50 and 100 mg/ml was assayed using -amylase and -amyloglucosidase. Acarbose was used as control and glucose liberation was determined by glucose oxidase method. Oral starch tolerance test (OSTT) and oral glucose tolerance test (OGTT) were determined for the plant extracts at concentrations 125, 250 and 500 mg/kg b.wt. on Sprague-Dawley rats. Blood glucose levels in rats treated with plant extracts and drugs (acarbose or metformin and glipizide) were measured at -30, 0, 45, 90 and 135 min. RESULTS: Compared to acarbose (IC(50)=1.2 µg/ml), water extracts of Pistacia atlantica, Rheum ribes and Sarcopoterium spinosum exerted significant dose dependent dual inhibition of -amylase and -glucosidase in in vitro enzymatic starch digestion bioassay, with IC(50)s; 46.98, 58.9 and 49.9 mg/ml, respectively. Comparable in vivo results were obtained for starch-fed rats, exhibiting significant acute postprandial antihyperglycemic efficacies. While Achillea santolina and Teucrium polium extracts lacked any favourable in vitro anti- -amylase and anti- -glucosidase effect, other modes of action can possibly explain their substantial acute antihyperglycemic activities in starch-treated rats. Except for Pistacia atlantica extracts, none of the investigated extracts qualified for improving the glucose intolerance in fasted rats on glucose loading. CONCLUSIONS: Pistacia atlantica, Rheum ribes and Sarcopoterium spinosum can be considered as potential candidates for amelioration/management of type 2 diabetes. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 133 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-27 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Hypoglycemic Agents Pharmacology Plants, Medicinal Achillea Chemistry Animals Blood Glucose Metabolism Diabetes Mellitus, Type 2 Drug Therapy Enzyme Inhibitors Isolation & Purification Ethnopharmacology Female Glipizide Glucan 1,4-alpha-glucosidase Antagonists & Inhibitors Glucose Intolerance Blood Humans In Vitro Techniques Jordan Medicine, Arabic Metformin Phytotherapy Pistacia Plant Extracts Rats Rats, Sprague-dawley Rheum Rosaceae Starch Teucrium Alpha-amylases Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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