NDLI: Prospective randomized controlled study of a Chinese herbal medicine compound Tangzu Yuyang Ointment for chronic diabetic foot ulcers: a preliminary report.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Shufa Zhao, Jianyong Liu, Jianping Xiang, Fei Lu, Debin Liu, Baoying Xu, Jing Zhang, Huimin Zhang, Qian Li, Xianwen Yu, Richeng Chen, Mingjun Wang, Xia Wang, Ye Chen, Bing
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Li S ( Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, China. shufali@163.com)
Abstract	AIM OF THE STUDY: The purpose of this study was to evaluate the efficacy and safety of a topical Chinese herbal medicine (CHM) compound Tangzu Yuyang Ointment (TYO) for treatment of chronic diabetic foot ulcers. MATERIALS AND METHODS: This multi-center, prospective, randomized, controlled and add-on clinical trial was conducted at seven centers in the China mainland. Fifty-seven patients with chronic diabetic foot ulcers of Wagner's ulcer grade 1-3 were enrolled in this study. Patients who were randomly assigned to the control group (n=28) received standard wound therapy (SWT), whereas those randomized to the treatment group (n=28) received SWT plus topical TYO. Only 48 patients who finished 24 weeks of observations were entered for data analysis. RESULTS: The TYO and SWT groups were comparable for baseline characteristics. Ulcer improvement was 79.2% in the TYO group and 41.7% in the SWT group (P=0.017) at 12 weeks, and 91.7% vs. 62.5% (P=0.036) at 24 weeks. The number of ulcers that were completely healed at 4, 12 and 24 weeks was similar in both groups, as were the numbers of adverse events. Healing time was 96±56 days (n=19) in the TYO group and 75±53 days (n=14) in the SWT group (P=0.271). CONCLUSION: TYO plus SWT is more effective than SWT in the management of chronic diabetic foot ulcers and has few side-effects.
File Format	HTM / HTML
ISSN	03788741
Issue Number	2
Volume Number	133
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-01-27
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Diabetic Foot Drug Therapy Drugs, Chinese Herbal Therapeutic Use Phytotherapy Adult Aged Aged, 80 And Over China Pathology Therapy Administration & Dosage Adverse Effects Ethnopharmacology Female Humans Male Middle Aged Ointments Plants, Medicinal Prospective Studies Treatment Outcome Wound Healing Drug Effects Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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