NDLI: Anti-plasmodial activity of the extracts of some Kenyan medicinal plants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rukunga, G. M. Gathirwa, J. W. Omar, S. A. Muregi, F. W. Muthaura, C. N. Kirira, P. G. Mungai, G. M. Kofi-Tsekpo, W. M.
Spatial Coverage	Kenya
Description	Country affiliation: Kenya Author Affiliation: Rukunga GM ( Kenya Medical Research Institute (KEMRI), PO BOX 54840, Nairobi, Kenya.)
Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: The spread of drug resistant Plasmodium falciparum strains necessitates search for alternative newer drugs for use against malaria. Medicinal plants used traditionally in preparation of herbal medicines for malaria are potential source of new anti-malarial drugs. AIM OF THE STUDY: To identify the anti-plasmodial potential of twelve plants used in preparing herbal remedies for malaria in Kilifi and Tharaka districts of Kenya. MATERIALS AND METHODS: Twelve plants used traditionally for anti-malarial therapy in Kilifi and Tharaka districts were extracted with water/methanol yielding twenty-three extracts. The extracts were tested against chloroquine sensitive (NF54) and resistant (ENT30) P. falciparum strains in vitro using (3)Hypoxanthine assay. RESULTS: Seven (30%) extracts showed activity against P. falciparum with IC(50) values below 20 microg/ml. The remaining 16 extracts showed low or no activity. The most active extracts were from Zanthoxylum chalybeum (Rutaceae) with an IC(50) value of 3.65 microg/ml, Cyperus articulatus (Cyperaceae) with 4.84mug/ml, and Cissampelos pareira (Menispermaceae) with 5.85 microg/ml. CONCLUSIONS: This study revealed plants, that are potential sources of anti-malarial compounds. Anti-plasmodial activities of extracts of T. simplicifolia, C. pareira, and C. articulatus are reported for the first time.
File Format	HTM / HTML
ISSN	03788741
Issue Number	2
Volume Number	121
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2009-01-21
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Antimalarials Pharmacology Plant Extracts Plasmodium Falciparum Drug Effects Animals Administration & Dosage Isolation & Purification Humans Inhibitory Concentration 50 Kenya Malaria, Falciparum Drug Therapy Medicine, African Traditional Parasitic Sensitivity Tests Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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