NDLI: Systemic exposure of quercetin after administration of feng-liao-chang-wei-kang granules to rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Junqing Liu, Xia Fu, Naiguang Liu, Mingsheng Tan, Yinfeng
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Zhang J ( Department of Pharmacy, Hainan Medical College, Hainan Provincial Key Laboratory of R&D of Tropical Herbs, Xueyuan Road No. 3, Haikou 571101, China.)
Abstract	AIM OF STUDY: The objective of this study was to observe the systemic exposure of quercetin (QCT) including its free and total concentration in rat blood samples following a single p.o. dose of feng-liao-chang-wei-kang granules (FLCWKG). MATERIALS AND METHODS: Six male rats were given the FLCHKG and the serial blood samples were collected. Fully or partially validated LC/MS/MS methods were developed to analyze the resulting biosamples. Various pharmacokinetic (PK) parameters were estimated from the plasma concentration versus time data using non-compartmental methods. RESULTS: Both methods for analysis of the free and total QCT plasma concentration are sensitive, specific, accurate and reliable. The PK parameters of free QCT after administration of FLCWKG, in comparison with total concentration, show a lower C(max) (32.4±8.2 ng/ml versus 164±49 ng/ml), a lower AUC(0â∞) (39.3±6.9 ng/ml h versus 313±16 ng/ml h), a shorter T(max) (0.17±0.00 h versus 0.83±1.01 h) and a similar t(1/2) (3.90±0.88 h versus 3.10±1.94 h), MRT(0ât) (2.27±0.10 h versus 2.86±0.41 h). CONCLUSIONS: Free QCT was quickly absorbed from gastrointestinal tract and circulated in blood at quite low concentration. The circulating flavonoids originating from this formula were dominantly conjugated derivatives.
File Format	HTM / HTML
ISSN	03788741
Issue Number	2
Volume Number	133
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-01-27
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Drugs, Chinese Herbal Administration & Dosage Pharmacokinetics Quercetin Animals Blood Chemical Analysis China Ethnopharmacology Male Medicine, Chinese Traditional Plants, Medicinal Chemistry Polygonum Blood Rats Rats, Sprague-dawley Saxifragaceae Tandem Mass Spectrometry Journal Article Research Support, Non-u.s. Gov't Validation Studies
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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