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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shenoy, Rekha R. Sudheendra, Arun T. Nayak, Pawan G. Paul, Piya Kutty, N. Gopalan Rao, C. Mallikarjuna |
| Spatial Coverage | India |
| Description | Country affiliation: India Author Affiliation: Shenoy RR ( Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.) |
| Abstract | UNLABELLED: ETHNO-PHARMACOLOGICAL RELEVANCE: The seeds of Sesamum indicum Linn. (Pedaliaceae) has been used traditionally for the treatment of wounds in Buldhana district of Maharashtra state. Sesamol is the main anti-oxidative constituent contained mainly in the processed sesame seed oil which has not been explored scientifically for its wound healing activity. AIM OF THE STUDY: To investigate the influence of sesamol (SM) on wound repair, both in normal and dexamethasone (DM) delayed healing processes in albino rats. MATERIALS AND METHODS: Incision, excision and dead space wounds were inflicted on albino rats (180-220 g) of either sex, under ketamine anaesthesia. Group I served as control, group II received SM 50 mg/kg i.p., group III was treated with dexamethasone (DM) i.m. (0.17 mg/kg) and SM+DM was given to group IV. The tensile strength, wound contraction, hydroxyproline, lysyl oxidase and total RNA and DNA levels (in granulation tissue) were measured. RESULTS: The tensile strength significantly (p<0.05) increased with SM at 471.40±14.66 g when compared to control at 300.60±9.16 g in normal and DM suppressed healing. No significant change was observed in duration of wound contraction and lysyl oxidase when compared to control at 2.98±0.10 mg. SM treated rats showed a significant (p<0.05) rise in hydroxyproline levels at 6.45±0.45 mg when compared to control at 1.75±0.20 mg. CONCLUSION: These results indicate that sesamol could be a promising drug in normal as well as delayed wound healing processes. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 133 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-27 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Benzodioxoles Pharmacology Phenols Sesamum Wound Healing Drug Effects Animals Antioxidants Isolation & Purification Dexamethasone Toxicity Ethnopharmacology Female Hydroxyproline Metabolism India Male Medicine, Traditional Phytotherapy Protein-lysine 6-oxidase Rats Rats, Wistar Seeds Chemistry Tensile Strength Physiology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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