NDLI: Hypotensive effect of aqueous extract of Averrhoa carambola L. (Oxalidaceae) in rats: an in vivo and in vitro approach.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Soncini, Roseli Santiago, Michael B. Orlandi, Lidiane Moraes, Gabriel O. I. Peloso, André Luiz M. Dos Santos, Marcelo H. Alves-da-Silva, Geraldo Paffaro, Valdemar A. Bento, Antonio C. Giusti-Paiva, Alexandre
Spatial Coverage	Brazil
Description	Country affiliation: Brazil Author Affiliation: Soncini R ( Department of Physiological Sciences, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas-MG, Brazil.)
Abstract	AIM OF THE STUDY: Averrhoa carambola L. (Oxalidaceae) leaves are used in Brazilian traditional medicine to treat hypertension. This study was conducted to evaluate the hypotensive effect of the aqueous extract of Averrhoa carambola (AEAc) and its underlying mechanisms in the isolated rat aorta. MATERIALS AND METHODS: The effect of AEAc on the mean arterial pressure (MAP) was determined in vivo in anesthetized rats. In vitro, thoracic aortic rings were isolated and suspended in organ baths, and the effects of AEAc were studied by means of isometric tension recording experiments. In HPLC analysis, the fingerprint chromatogram of AEAc was established. RESULTS: In normotensive rats, AEAc (12.5-50.0 mg/kg, i.v.) induced dose-dependent hypotension. In vitro, AEAc caused a depression in the E(max) response to phenylephrine without a change in sensibility. Also, in a depolarized Ca(2+)-free medium, AEAc inhibited CaCl(2)-induced contractions and caused a concentration-dependent rightward shift of the response curves, indicating that AEAc inhibited the contractile mechanisms involving extracellular Ca(2+) influx. CONCLUSIONS: These results demonstrate the hypotensive effects of AEAc, and these effects may, in part, be due to the inhibition of Ca(2+), which supports previous claims of its traditional use.
File Format	HTM / HTML
ISSN	03788741
Issue Number	2
Volume Number	133
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-01-27
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Antihypertensive Agents Pharmacology Plants, Medicinal Chemistry Animals Isolation & Purification Aorta, Thoracic Drug Effects Physiology Blood Pressure Brazil Calcium Channel Blockers Ethnopharmacology Hypertension Drug Therapy In Vitro Techniques Male Medicine, Traditional Muscle Relaxation Muscle, Smooth, Vascular Phenylephrine Phytotherapy Plant Extracts Plant Leaves Rats Rats, Wistar Water Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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