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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yi, Tao Chen, Hu-Biao Zhao, Zhong-Zhen Yu, Zhi-Ling Jiang, Zhi-Hong |
| Spatial Coverage | China |
| Description | Author Affiliation: Yi T ( School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, PR China.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: 'Dragon's Blood' has been used as a medicine since ancient times by many cultures. In traditional Chinese medicine, the resin obtained from Daemonorops draco (RDD) and the resin from Dracaena cochinchinensis (RDC) are equally prescribed as 'Dragon's Blood' for facilitating blood circulation. AIM OF THE STUDY: To verify the traditional efficacy and elucidate the mechanism, the present study compared the chemical profiles and the pharmacological effects of two species of 'Dragon's Blood' mainly used in China. MATERIALS AND METHODS: A UPLC-MS fingerprinting method was developed to compare the chemical profiles of the two medicines. The anti-platelet aggregation effects of the two medicines induced by arachidonic acid (AA) were investigated. RESULTS: The chemical profiles of these two species of 'Dragon's Blood' were significantly different. The characteristic constituents were found to be: flavanes in RDD and stilbenes in RDC. In the in vivo platelet inhibition test, performed with the dose of 200 mg/kg on rats, the peak inhibitory effects of RDD and RDC were 35.8% and 27.6%, respectively, compared with the control group. With the in vitro concentrations of 0.2, 0.4 and 0.8 mg/ml, RDD exerted significant inhibition of aggregation by 18.7%, 20.0%, and 61.6%, respectively, and RDC exerted significant inhibition of aggregation by 13.3%, 20.2%, and 31.6%, respectively. CONCLUSION: The fingerprinting method used here is suitable for distinguishing them. All pharmacological tests indicated that RDD was more potent than RDC against platelet aggregation. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 133 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-27 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Drugs, Chinese Herbal Chemistry Pharmacology Plant Extracts Platelet Aggregation Inhibitors Animals Arecaceae China Dracaena Ethnopharmacology In Vitro Techniques Male Medicine, Chinese Traditional Platelet Aggregation Drug Effects Rats Rats, Sprague-dawley Resins, Plant Spectrometry, Mass, Electrospray Ionization Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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