NDLI: Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Luo, Fu-Cheng Wang, Sheng-Dong Qi, Lei Song, Jun-Ying Lv, Tao Bai, Jie
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Luo FC ( College of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China.)
Abstract	AIM OF THE STUDY: Panaxatriol saponins (PTS), the main constituents extracted from Panax notoginseng, a Chinese herbal medicine, has been shown to be an effective agent on various diseases. Our previous study has demonstrated that PTS is an inducer of thioredoxin-1 (Trx-1) and has a possible potential as a therapeutic agent for Parkinson's disease (PD). However, the effect of PTS on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in vivo is unknown. MATERIALS AND METHODS: Using locomotor activity test and traction test, we detected the effect of PTS on MPTP-induced behavioral impairment. Tyrosine hydroxylase, Trx-1, cyclooxygenase-2, pro-caspase-9, pro-caspase-12 and caspase-3 expressions in the anatomical region of substantia nigra pars compacta (SNc) were tested by Western blot. RESULTS: PTS provided neuroprotection against the loss of dopaminergic neurons and behavioral impairment caused by MPTP. MPTP-induced neuronal death in the SNc was suppressed by PTS through increasing Trx-1 expression, suppressing cyclooxygenase-2 over-expression and inhibiting mitochondria-mediated apoptosis. CONCLUSIONS: PTS, an inducer of Trx-1, has pluripharmacological properties in the protection against PD including enhancing antioxidant activity, acting as neurotrophic factor, modulating inflammation and inhibiting mitochondria-mediated apoptosis.
File Format	HTM / HTML
ISSN	03788741
Issue Number	2
Volume Number	133
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-01-27
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Drugs, Chinese Herbal Pharmacology Ginsenosides Mptp Poisoning Prevention & Control Neuroprotective Agents Panax Notoginseng Chemistry Saponins Animals Apoptosis Drug Effects Caspase 12 Metabolism Caspase 3 Caspase 9 China Cyclooxygenase 2 Enzyme Precursors Ethnopharmacology Isolation & Purification Enzymology Pathology Male Mice Mitochondria Motor Activity Neurons Neurotoxins Toxicity Substantia Nigra Tyrosine 3-monooxygenase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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