NDLI: A contamination aware droplet routing algorithm for digital microfluidic biochips

Content Provider	IEEE Xplore Digital Library
Author	Tsung-Wei Huang Chun-Hsien Lin Tsung-Yi Ho
Copyright Year	2009
Description	Author affiliation: Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan (Tsung-Wei Huang; Chun-Hsien Lin; Tsung-Yi Ho)
Abstract	In this paper, we propose a contamination aware droplet routing algorithm for digital microfluidic biochips (DMFBs). To reduce the routing complexities and the used cells, we first construct preferred routing tracks by analyzing the global moving vector of droplets to guide the droplet routing. To cope with contaminations within one subproblem, we first apply a k-shortest path routing technique to minimize the contaminated spots. Then, to take advantage of multiple wash droplets, we adopt a minimum cost circulation algorithm (MCC) for optimal wash-droplet routing to simultaneously minimize used cells and the cleaning time. Furthermore, a look-ahead prediction technique is used to determine the contaminations between successive subproblems. After that, we can simultaneously clean both contaminations within one subproblem and those between successive subproblems by using the MCC-based algorithm to reduce the execution time and the used cells. Based on four widely used bioassays, our algorithm reduces the used cells and the execution time significantly compared with the state-of-the-art algorithm.
Starting Page	151
Ending Page	156
File Size	596870
Page Count	6
File Format	PDF
ISBN	9781605588001
ISSN	10923152
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-11-02
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Association for Computing Machinery, Inc. (ACM)
Subject Keyword	Contamination Routing Microfluidics Electrodes Immune system Proteins Computer science Cost function Cleaning Reservoirs
Content Type	Text
Resource Type	Article
Subject	Computer Graphics and Computer-Aided Design Computer Science Applications Software

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