NDLI: Quantitative Description and Model of Molecule Transport through Skin

Content Provider	IEEE Xplore Digital Library
Author	Bao Jiali Wang Hong Wang Huiping Ge Jiguang
Copyright Year	2004
Description	Author affiliation: College of Medicine, Zhejiang University, Hangzhou, 310006, China, Email: baojl@zju.edu.cn, Tel: 86-571-87217390 (Bao Jiali)
Abstract	The illustration of the electrical properties of skin and quantitative relations provides the theory and method for transdermal drug delivery by electroporation. The paper puts forward an electrical model of skin including conductance of appendageal, lipid, lipid-corneocyte matrix pathway and Nernst potential of charged drug molecule. Leakage experiments with Tinidazole as pattern mass were carried out with three groups, each of which contained 15 protocols. The result indicates that (1) we obtained that equivalent resistance RTof side-by-side permeation chambers and one RAof transdermal decreased along with initial voltage of pulse increased using logarithm trend line fitting, but the RTand RAwere gained along with pulse voltage decreased during pulse duty; (2) Even if same pulse protocol, Tinidazole permeation fluxes were difference 0 − 4 orders from each other for SC of different position at same time. The transdermal potential is actual exist in the molecular to pass through skin. In is more significant that conductance Ga, Gland Gcis described permeability of molecular through skin. And it shows that electrical model of skin to expatiate quantify relationship between electrical property and molecular flow is very effective.
Starting Page	3539
Ending Page	3542
File Size	212922
Page Count	4
File Format	PDF
ISBN	0780384393
DOI	10.1109/IEMBS.2004.1403995
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-09-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Skin Voltage Permeability Lipidomics Drug delivery Protocols Epidermis Electric resistance Conductivity Fluorescence electricity model of skin Transdermal drug delivery (TDD) permeable flux Stratum Corneum (SC)
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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