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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Fu, Y. Weng, Z. |
| Copyright Year | 2004 |
| Description | Author affiliation: Bioinformatics Program, Boston Univ., MA, USA (Fu, Y.; Weng, Z.) |
| Abstract | This paper describes a novel approach to constructing position-specific weight matrices (PWM) based on the transcription factor binding site (TFBS) data provide by the TRANSFAC database, and the comparison of the thus generated PWMs with the original TRANSFAC matrices. Multiple local sequence alignment was performed on the TFBSs of each transcription factor. Several different alignment programs were tested and their matrices were compared to the original TRANSFAC matrices. One of the alignment programs, GLAM, produced comparable matrices in terms of the average ranking of true positive sites across the whole test set of sequences. |
| Starting Page | 2856 |
| Ending Page | 2859 |
| File Size | 204967 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780384393 |
| DOI | 10.1109/IEMBS.2004.1403814 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2004-09-01 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Pulse width modulation Testing Bioinformatics Databases Genomics Dynamic programming Sampling methods Information retrieval Matrix converters Performance evaluation PWM TRANSFAC GLAM |
| Content Type | Text |
| Resource Type | Article |
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