NDLI: Linear system analysis of ion channel modulation in rod photoreceptors under dim light conditions

Content Provider	IEEE Xplore Digital Library
Author	Liu, X.-D. Kourennyi, D.E.
Copyright Year	2004
Description	Author affiliation: Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA (Liu, X.-D.; Kourennyi, D.E.)
Abstract	Rod photoreceptors perform the task of night vision. The dynamics of dim light response is mainly determined by non-inactivating potassium Kx channels in the inner segment, manifested by such a feature as high-pass filtering. The L-type Ca/sup 2+/ channels function as the voltage dependent actuator governing synaptic transmission from rods to the second order cells. Modulation of these ion channels can affect physiological features of rods. We introduced here an analytical approach to construct a linear circuit model of the rod membrane to study the effects of modulation of ion channels on rod function. The effects of tetraethylammonium (TEA) and Zn/sup 2+/ were analyzed in frequency domain. The obtained results were consistent with the computational and experimental studies, which showed that TEA attenuated the high-pass filtering whereas Zn/sup 2+/ enhanced it. The role of Ca/sup 2+/ channels in the dynamics of light response was also investigated to show that the activation gate exhibited a larger impact on the overall frequency response than the inactivation gate. Linearization of ion channels for small perturbations provides an attractive alternative method to quantitatively evaluate the physiological significance of the effects of the modulation of ion channels. The resultant linear system may help reveal important features of neurons which can hardly be obtained otherwise.
Starting Page	4037
Ending Page	4040
File Size	348256
Page Count	4
File Format	PDF
ISBN	0780384393
DOI	10.1109/IEMBS.2004.1404127
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-09-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Linear systems Optical modulation Photoreceptors Filtering Zinc Night vision Voltage Actuators Neurotransmitters Linear circuits light response Ion channels modulation neurons retina rod photoreceptors linear circuit frequency response
Content Type	Text
Resource Type	Article

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