NDLI: Detection of expiratory flow limitation during mechanical ventilation: a simulation study

Content Provider	IEEE Xplore Digital Library
Author	Brighenti, C. Barbini, P. Gnudi, G.
Copyright Year	2004
Description	Author affiliation: Dipartimento di Elettronica, Informatica e Sistemistica, Bologna Univ., Cesena, Italy (Brighenti, C.)
Abstract	Expiratory flow limitation (EFL) is frequent in mechanically ventilated patients with obstructive pulmonary disease and its prompt detection is important to optimize respiratory assistance. The present study aims to compare by simulation two methods for the detection of flow limitation in intensive care unit: the negative expiratory pressure (NEP) method and the external resistance (/spl Delta/R) method. To this purpose, a non linear dynamic morphometric model of breathing mechanics, derived from the Weibel symmetrical description of lungs, was used to simulate a normal and an obstructive respiratory condition during artificial ventilation. Both methods revealed the presence of EFL in the pathological case. The NEP method seems to promote the collapse of the upper and intermediate airways, so producing an overestimation of the pathology result. On the contrary, during the /spl Delta/R maneuver the same airways increase their radius and, therefore, EFL appears underestimated. The /spl Delta/R method appears less practical with respect to the NEP method, because of the procedure required to select the appropriate resistance degree. Moreover the flow limited portion of expiration estimated by the /spl Delta/R technique sounds rather dependent on the choice of the external resistance level.
Starting Page	3921
Ending Page	3924
File Size	314152
Page Count	4
File Format	PDF
ISBN	0780384393
DOI	10.1109/IEMBS.2004.1404096
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-09-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ventilation Immune system Lungs Pathology Diseases Medical treatment Humans Character generation Gases Equations external resistance Breathing mechanics expiratory flow limitation mechanical ventilation morphometric model negative expiratory pressure
Content Type	Text
Resource Type	Article

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