NDLI: Women Have a Greater Ventilatory Responses to Upper Airway Obstruction Than Men

Content Provider	IEEE Xplore Digital Library
Author	Pichard, L.E. Patil, S.P. Gladmon, E. Smith, P.L. Schwartz, A.R. Schneider, H.
Copyright Year	2004
Description	Author affiliation: Division of Pulmonary Medicine, Johns Hopkins University, Baltimore, MD (Pichard, L.E.)
Abstract	We e xamined whether gender specific differences exist in defending inspiratory tidal volumes in the face of upper airway obstruction. In normal weight- and aged-matched men (n=9) and women (n=9), we induced upper airway obstruction with inspiratory flow limitation during NREM sleep by exposing individuals to sub-atmospheric nasal pressure. The mean inspiratory airflow was used to define three distinct levels of upper airway obstruction, based on a mean inspiratory airflow of 175-225 ml/s, 125-175 ml/s and 75-125 ml/s. While duty cycle responses were similar between genders, women had a greater response in TTOTat all flow limited conditions. (p<0.05). However, the greater response in TTOTled to a more pronounced decline in tidal volume in women compared to men (p<0.05), particularly during the mild and moderate upper airway obstruction. Our data demonstrate that the respiratory rate determines the tidal volume during periods of upper airway obstruction and indicate that individuals with a higher respiratory rate are at risk to develop hypoventilation in face of upper airway obstruction. Because women have a more brisk response in the respiratory rate than men, this may explain the difference in the expression of sleep disordered breathing between genders.
Starting Page	3878
Ending Page	3880
File Size	303207
Page Count	3
File Format	PDF
ISBN	0780384393
DOI	10.1109/IEMBS.2004.1404085
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-09-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ventilation Sleep apnea Recruitment Hypertension Protocols Electromyography Samarium Electrooculography Electroencephalography Data analysis normals ventilation upper airway obstruction flow limitation obstructive sleep apnea sleep gender
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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