NDLI: A Comprehensive Physiological Model of Circulation Enables Automatic Piloting of Hemodynamics in Patients with Acute Heart Failure

Content Provider	IEEE Xplore Digital Library
Author	Sugimachi, M. Uemura, K. Kawada, T. Inagaki, M. Sunagawa, K. Uemura, K. Kawada, T. Inagaki, M. Sunagawa, K.
Copyright Year	2004
Description	Author affiliation: Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan (Sugimachi, M.)
Abstract	A comprehensive physiological model of the whole circulation is mandatory to quantitatively diagnose pathophysiology and to guide an appropriate treatment. Such a model would enable automatic piloting of hemodynamics in patients with acute heart failure. By extending Guyton's model, so as to deal with heart failure predominantly affecting left heart and to quantify left atrial pressure, we constructed such a model consisting of a venous return (VR) surface and a cardiac output (CO) curve. VR surface, the integrated property of systemic and pulmonary vascular beds, relates VR and left and right atrial pressures (PLA, PRA) linearly as VR = V/W - GRPRA- GLPLA, given total blood volume (V). CO curve, the pumping ability of hearts, relates CO and either PLAor PRAapproximately by logarithmic functions, respectively, as CO = SL[ln (PLA- BL) + CL] = SR[ln (PRA- BR) + CR]. The slopes (SRand SL) of CO curve mainly describes the pump performance. W, GR, GL, BR, BL, CRand CLare parameters. We validate the model with animal experiments. Parameters W, G's, B's and C's were relatively constant in 19 dogs. In other 8 dogs, with or without acute left heart failure, we determined V and S's from a single set of CO, PRA, PLAand standard parameter values. We then predicted hemodynamics (CO, PRA, PLA) for altered V from –8 to +8 ml/kg. We identified standard values of parameters as W (0.13 min), GR(19.6 ml/min/kg/mmHg), GL(3.5 ml/min/kg/mmHg). BL(2.1 mmHg), CL
Starting Page	3716
Ending Page	3719
File Size	1363949
Page Count	4
File Format	PDF
ISBN	0780384393
DOI	10.1109/IEMBS.2004.1404043
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-09-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Hemodynamics Heart Virtual reality Blood Cardiology Biomedical monitoring Surface treatment Predictive models Medical treatment Animals integrated cardiac output curve circulatory equilibrium venous return surface
Content Type	Text
Resource Type	Article

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