NDLI: BioMEMs

Content Provider	IEEE Xplore Digital Library
Author	Ziaie, B. Siegel, R.A.
Copyright Year	2004
Abstract	Summary form only given. Environmentally sensitive hydrogels offer unique opportunities for smart flow control in microfluidic systems. These tangled networks of cross-linked polymer chains, immersed in a solvent, manifest a reversible and abrupt swelling phase transition in response to changes in environmental factors such as glucose concentration, pH, electric field, temperature, and light. This transition often results in an abrupt volume change (swelling or shrinking) that can be as large as 1000 fold or more. Because of this property, hydrogels are attractive candidates as components of microactuators operating in aqueous media such as body fluids. For example, the volume phase transition in these materials can be harnessed in smart microfluidic components used for implantable drug delivery systems. In this talk, we will discuss several hydrogel-actuated MEMS-based microdevices for smart microflow control developed in our laboratories at the University of Minnesota. These include: 1) a hydrogel-actuated microvalve with a porous back-plate, 2) a hydrogel-gated smart flow controller, 3) a microvalve with double side tethered structure for the entrapment of hydrogel, and 4) a wireless passive glucose transponder. Our emphasis is particularly on lightly crosslinked poly(methacrylamidophenylboronic acid-co-acylamide) hydrogel that swell monotonically at pH 7.4 with exposure to increasing concentrations of glucose
Starting Page	5129
Ending Page	5129
File Size	818684
Page Count	1
File Format	PDF
ISBN	0780384393
DOI	10.1109/IEMBS.2004.1404422
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-09-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sugar Microfluidics Microvalves Control systems Polymers Solvents Environmental factors Temperature sensors Microactuators Phase change materials regulations image processing image analysis CAD industry
Content Type	Text
Resource Type	Article

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