NDLI: Caspase-3 Activation by Exponential Decay Nanosecond Pulsed Electric Fields on Tumor-Bearing BALB/c Nude Mice <emphasis emphasistype=italic>In Vivo</emphasis>

Content Provider	IEEE Xplore Digital Library
Author	Yan Mi Chenguo Yao Chengxiang Li Caixin Sun Junying Tang Fangli Yang Yanqing Wen
Copyright Year	1973
Abstract	In order to study the apoptosis-induction effects of exponential decay nanosecond pulsed electric fields (EDnsPEF) in vivo, tumor models in 20 female BALB/c nude mice were established by inoculating them with human melanoma cells A375. These mice were randomly divided into treated group (exposed to EDnsPEF with intensity of 20 kV/cm and duration of 300 ns) and control group equally. Twenty days later, tumor growth in the treated group was effectively inhibited (P <; 0.01 compared with that in control group), typical morphological apoptosis characteristics in ultrastructure were observed by transmission electron microscope, and expression of caspase-3 and caspase-3 messenger ribonucleic acid were obviously increased (P <; 0.01) using immunofluorescence and RT-PCR, respectively. These experimental results contributed evidence of tumor-growth inhibition by EDnsPEF exposure in vivo. The mechanism was apoptosis-induction effects of EDnsPEF on cancer cells by activating caspase-3. This study presented in vivo evidence of caspase-3 activation for apoptosis-induction effects of EDnsPEF, and this supported possible drug-free tumor therapy utilizing EDnsPEF.
Sponsorship	IEEE Nuclear and Plasma Sciences Society
Starting Page	1963
Ending Page	1971
Page Count	9
File Size	757691
File Format	PDF
ISSN	00933813
Volume Number	38
Issue Number	8
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mice In vivo Neoplasms Humans Malignant tumors Transmission electron microscopy RNA Immune system Cancer Medical treatment human melanoma cells A375 Apoptosis BALB/c nude mouse caspase-3 exponential decay nanosecond pulsed electric fields (EDnsPEF)
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Condensed Matter Physics

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