NDLI: Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune uveoretinitis.

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Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune uveoretinitis.

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Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune uveoretinitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Higaki, Megumu Tsuneoka, Hiroshi Ishihara, Tsutomu Akiyama, Goichi Sakai, Tsutomu
Description	Country affiliation: Japan Author Affiliation: Sakai T ( Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan. tstmski@jikei.ac.jp)
Abstract	PURPOSE: The therapeutic effects of betamethasone phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly(lactic acid) (PLA) homopolymers and PEG-block-PLA copolymers (stealth nanosteroids) were examined in an experimental autoimmune uveoretinitis (EAU) model in Lewis rats. METHODS: EAU was induced by S-antigen peptide in Lewis rats. Accumulation of systemically administered Cy7-labeled stealth nanoparticles in inflamed eyes of rats with EAU was assessed using in vivo fluorescence imaging, and the therapeutic effect of stealth nanosteroids, nonstealth nanosteroids, or saline on EAU was examined. The eyes were obtained 7 days after the treatment, and the histologic score was determined using pathologic findings. The expression of inflammatory cytokines including IL-6, IL-17, and VEGF was determined immunohistochemically. RESULTS: Cy7-stealth nanoparticles accumulated in inflamed eyes of rats with EAU and remained in situ for a 3-day period. Systemically administered stealth nanosteroids (100 µg of BP) reduced the clinical scores of rats with EAU within 1 day and maintained the effect for 2 weeks. This treatment also decreased the histologic scores and the expression of inflammatory cytokines in the retina of EAU. CONCLUSIONS: The strong therapeutic benefit on EAU obtained with the stealth nanosteroids may have been due to prolonged blood circulation and targeting to the inflamed uvea and retina, in addition to sustained release in situ.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-18
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoimmune Diseases Drug Therapy Betamethasone Analogs & Derivatives Lactic Acid Administration & Dosage Polyethylene Glycols Polymers Retinitis Uveitis Animals Metabolism Pathology Pharmacokinetics Biocompatible Materials Biological Availability Delayed-action Preparations Drug Carriers Drug Compounding Injections, Intravenous Microscopy, Confocal Nanoparticles Polyesters Rats, Inbred Lew Tissue Distribution Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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