NDLI: Quantification of the therapeutic response of intraretinal, subretinal, and subpigment epithelial compartments in exudative AMD during anti-VEGF therapy.

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Quantification of the therapeutic response of intraretinal, subretinal, and subpigment epithelial compartments in exudative AMD during anti-VEGF therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schmidt-Erfurth, Ursula Margarethe Prünte, Christian Schütze, Christopher Stock, Geraldine Schlanitz, Ferdinand Simader, Christian Ahlers, Christian Golbaz, Isabelle Schriefl, Sabine
Description	Country affiliation: Austria Author Affiliation: Golbaz I ( Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.)
Abstract	PURPOSE: To analyze the functional and morphologic effects of different ranibizumab treatment regimens on retinal and subretinal as well as sub-RPE compartments in neovascular age-related macular degeneration (nAMD) using spectral-domain optical coherence tomography (SD-OCT) and manual segmentation software. METHODS: Twenty-seven eyes of 27 patients with nAMD were examined over a 12-month period. Two treatment arms received either monthly or quarterly administered intravitreal ranibizumab. Intraretinal, subretinal, and sub-RPE volume equivalents were delineated using manual segmentation software over a defined series of B-scans obtained by SD-OCT. The mean area in pixels was calculated for each compartment at each time interval. RESULTS: SD-OCT and manual segmentation allowed for exact identification of intraretinal, subretinal and sub-RPE compartments and their responses to different treatment regimens. The loading dose demonstrated a corresponding treatment effect on all anatomic parameters. In contrast to the sub-RPE compartment, intraretinal fluid accumulation and subretinal fluid accumulation (SRFA) demonstrated an immediate response to ranibizumab therapy. The overall plasticity of the morphologic response declined over time. In general, SRFA demonstrated greater sensitivity for therapeutic effects and was more frequently associated with recurrent disease. CONCLUSIONS: An exact quantification of fluid in different anatomic compartments based on SD-OCT imaging, using appropriate segmentation software systems, may be useful to determine optimal treatment and retreatment parameters and explains the lack of correlation of best-corrected visual acuity and conventional OCT values.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Angiogenesis Inhibitors Therapeutic Use Antibodies, Monoclonal Choroidal Neovascularization Drug Therapy Retina Pathology Retinal Pigment Epithelium Vascular Endothelial Growth Factor A Antagonists & Inhibitors Wet Macular Degeneration Antibodies, Monoclonal, Humanized Diagnosis Metabolism Exudates And Transudates Imaging, Three-dimensional Intravitreal Injections Ranibizumab Drug Effects Subretinal Fluid Tomography, Optical Coherence Visual Acuity Physiology Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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