NDLI: Light-induced retinal degeneration correlates with changes in iron metabolism gene expression, ferritin level, and aging.

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Light-induced retinal degeneration correlates with changes in iron metabolism gene expression, ferritin level, and aging.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Picard, Emilie Beaumont, Carole Ranchon-Cole, Isabelle Jonet, Laurent Courtois, Yves Jeanny, Jean-Claude Behar-Cohen, Francine
Description	Country affiliation: France Author Affiliation: Picard E ( Institut National de la Santé et de la Recherche Médicale, U872, Paris, France. picardemilie@gmail.com)
Abstract	PURPOSE: Retinal degeneration is associated with iron accumulation in several rodent models in which iron-regulating proteins are impaired. Oxidative stress is catalyzed by unbound iron. METHODS: The role of the heavy chain of ferritin, which sequesters iron, in regulating the thickness of the photoreceptor nuclear layer in the 4- and 16-month-old wild-type H ferritin (HFt(+/+)) and heterozygous H ferritin (HFt(+/-)) mice was investigated, before and 12 days after exposure to 13,000-lux light for 24 hours. The regulation of gene expression of the various proteins involved in iron homeostasis, such as transferrin, transferrin receptor, hephaestin, ferroportin, iron regulatory proteins 1 and 2, hepcidin, ceruloplasmin, and heme-oxygenase 1, was analyzed by quantitative (q)RT-PCR during exposure (2, 12, and 24 hours) and 24 hours after 1 day of exposure in the 4-month-old HFt(+/+) and HFt(+/-) mouse retinas. RESULTS: Retinal degeneration in the 4-month-old HFt(+/-) mice was more extensive than in the HFt(+/+) mice. Yet, it was more extensive in both of the 16-month-old mouse groups, revealing the combined effect of age and excessive light. Injury caused by excessive light modified the temporal gene expression of iron-regulating proteins similarly in the HFt(+/-) and HFt(+/+) mice. CONCLUSIONS: Loss of one allele of H ferritin appears to increase light-induced degeneration. This study highlighted that oxidative stress related to light-induced injury is associated with major changes in gene expression of iron metabolism proteins.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-10
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Physiology Apoferritins Genetics Gene Expression Regulation Iron-binding Proteins Radiation Injuries, Experimental Retina Radiation Effects Retinal Degeneration Animals Metabolism Cation Transport Proteins Enzyme-linked Immunosorbent Assay Fluorescent Antibody Technique, Indirect Mice Mice, Inbred Balb C Oxidative Stress Rna, Messenger Etiology Reverse Transcriptase Polymerase Chain Reaction Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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