NDLI: Prophylactic effect of intravenous moxifloxacin in a rabbit model of Staphylococcus epidermidis endophthalmitis.

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Prophylactic effect of intravenous moxifloxacin in a rabbit model of Staphylococcus epidermidis endophthalmitis.

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Prophylactic effect of intravenous moxifloxacin in a rabbit model of Staphylococcus epidermidis endophthalmitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Si Yeol Kim, Jung Yeul
Description	Author Affiliation: Kim JY ( Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea. kimjy@cnu.ac.kr)
Abstract	PURPOSE: To compare the prophylactic effects of intravenous moxifloxacin and vancomycin for Staphylococcus epidermidis endophthalmitis in a rabbit model. METHODS: Albino rabbits (n = 60) were divided into three groups. Intravenous moxifloxacin was injected into 20 animals (group 1), and intravenous vancomycin was injected into 20 animals (group 2). In group 3, 20 animals received 0.9% normal saline. After these prophylactic intravenous injections, the right eyes of the 60 rabbits were injected intravitreally with 10(5) colony-forming units of S. epidermidis. Intravenous antibiotic injection was repeated on days 1, 2, and 3 after infection. Clinical features were evaluated on days 1, 3, 5, and 7 after infection, and 10 eyes per group were then enucleated for histopathologic examination. Vitreous aspirates were obtained for bacterial culture on days 1, 3, 5, and 7 after infection from the other 10 eyes per group. RESULTS: The moxifloxacin group showed significant clinical effects at days 1, 3, 5, and 7 (P = 0.019, < 0.001, < 0.001, and < 0.001, respectively); bacteriologic results at days 1, 3, 5, and 7 (P = 0.001, 0.002, 0.01, and 0.002, respectively); and histopathologic results, with less severe inflammation and relatively well-preserved retinal architecture. However, no difference was detected between the vancomycin group and control group in any aspect examined. CONCLUSIONS: Intravenously administered moxifloxacin showed a significant prophylactic effect against S. epidermidis endophthalmitis. Thus, intravenous moxifloxacin may be a useful prophylactic medication against postoperative endophthalmitis.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-25
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anti-infective Agents Therapeutic Use Antibiotic Prophylaxis Aza Compounds Disease Models, Animal Endophthalmitis Drug Therapy Eye Infections, Bacterial Quinolines Staphylococcal Infections Animals Administration & Dosage Colony Count, Microbial Microbiology Fluoroquinolones Injections, Intravenous Rabbits Staphylococcus Epidermidis Isolation & Purification Pathogenicity Vancomycin Comparative Study Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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