NDLI: Differentially expressed genes associated with human limbal epithelial phenotypes: new molecules that potentially facilitate selection of stem cell-enriched populations.

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Differentially expressed genes associated with human limbal epithelial phenotypes: new molecules that potentially facilitate selection of stem cell-enriched populations.

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Differentially expressed genes associated with human limbal epithelial phenotypes: new molecules that potentially facilitate selection of stem cell-enriched populations.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Szanto, Attila Berta, András Takács, Lili Bähr-Ivacevic, Tomi Tóth, Eniko Losonczy, Gergely Vereb, György Benes, Vladimir
Description	Country affiliation: Hungary Author Affiliation: Takács L ( Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary. ltakacs@dote.hu)
Abstract	PURPOSE: The aim of this study was to identify differentially expressed genes in the human limbal epithelium by microarray analysis. METHODS: Total RNA isolates of human limbal and central corneal epithelia were used after transcription for hybridization on whole human genome expression microarrays. A set of differentially expressed genes detected by both microarrays was established. In the case of eight selected molecules, microarray results were confirmed by qRT-PCR, and protein expression in the cornea was examined by confocal immunofluorescence microscopy. Colocalization with the putative stem cell marker C/EBPÎ´ was also examined. RESULTS: The authors established a database of 126 limbal overexpressed genes. qRT-PCR confirmed microarray results in all examined cases (SPON1, IFITM1, ITM2A, PHLDA1, CXCR4, FZD7, DCT, DKK4). Limbal localization of the protein product of SPON1, IFITM1, ITM2A, CXCR4, and DKK4 was shown with confocal immunofluorescence microscopy. SPON1, IFITM1, and ITM2A signals mostly colocalized with C/EBPÎ´-positive putative resting limbal stem cells. CONCLUSIONS: By detecting several new differentially expressed genes in the human corneal limbus, this study further expands current knowledge on the molecular signature of limbal epithelial stem cells. Plasma membrane localization of IFITM1 and ITM2A suggests their potential usefulness as targets to select stem cell-enriched populations from the limbal epithelium.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-10
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Epithelium, Corneal Cytology Metabolism Gene Expression Profiling Gene Expression Regulation Physiology Limbus Corneae Stem Cells Biological Markers Ccaat-enhancer-binding Protein-delta Genetics Epithelial Cells Eye Proteins Microscopy, Confocal Oligonucleotide Array Sequence Analysis Phenotype Rna, Messenger Reverse Transcriptase Polymerase Chain Reaction Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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