NDLI: Relationship of central corneal thickness with optic disc parameters: the Singapore Malay Eye Study.

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Relationship of central corneal thickness with optic disc parameters: the Singapore Malay Eye Study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wong, Tien-Yin Loon, Seng-Chee Wu, Ren-Yi Zheng, Ying-Feng Cheung, Carol Yim-Lui Aung, Tin Chauhan, Balwantray C.
Spatial Coverage	Singapore
Description	Country affiliation: Singapore Author Affiliation: Wu RY ( Singapore Eye Research Institute and Singapore National Eye Center, Singapore.)
Abstract	PURPOSE: To examine the relationship of central corneal thickness (CCT) with optic disc parameters measured by confocal scanning laser ophthalmoloscopy in a Malay population. METHODS: This was a population-based cross-sectional study of Asian Malay adults aged 40-80 years living in Singapore. Participants had a standardized interview, examination, and imaging at a study clinic. CCT was measured with an ultrasound pachymeter. Confocal scanning laser imaging was performed on all participants to obtain optic disc parameters. Multivariate regression analyses controlling for age, sex, intraocular pressure, and other potentially confounding factors were conducted separately for disc area, rim area, cup-to-disc ratio, and mean cup depth. RESULTS: Of the 3280 participants in the study, 2525 (77.0%) right eyes with reliable confocal scanning laser tomography images were included in this analysis, with 48 eyes defined to have primary open-angle glaucoma (POAG). In POAG subjects, CCT was positively correlated with rim area (regression coefficient of 0.372 mm(2) per 100 µm CCT increase; P = 0.035) and negatively correlated with cup-to-disc area ratio (-0.160 per 100 µm CCT increase; P = 0.024). There was no relationship between CCT and disc size (P = 0.088). In the 2468 subjects without glaucoma, there were no associations between CCT and confocal scanning laser tomography parameters. CONCLUSIONS: In this population-based study, decreased CCT was associated with lower rim area and greater cup-to-disc area in subjects with POAG, but not in subjects without glaucoma.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-10
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cornea Pathology Glaucoma, Open-angle Diagnosis Optic Disk Optic Nerve Diseases Asian Continental Ancestry Group Ethnology Body Weights And Measures Cross-sectional Studies Intraocular Pressure Ophthalmoscopy Singapore Epidemiology Tomography Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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