NDLI: Revealing Henle's fiber layer using spectral domain optical coherence tomography.

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Revealing Henle's fiber layer using spectral domain optical coherence tomography.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roorda, Austin Lujan, Brandon J. Knighton, Robert W. Carroll, Joseph
Description	Country affiliation: United States Author Affiliation: Lujan BJ ( Department of Vision Science, School of Optometry, University of California, Berkeley, California, USA. blujan@berkeley.edu)
Abstract	PURPOSE: Spectral domain optical coherence tomography (SD-OCT) uses infrared light to visualize the reflectivity of structures of differing optical properties within the retina. Despite their presence on histologic studies, traditionally acquired SD-OCT images are unable to delineate the axons of photoreceptor nuclei, Henle's fiber layer (HFL). The authors present a new method to reliably identify HFL by varying the entry position of the SD-OCT beam through the pupil. METHODS: Fifteen eyes from 11 subjects with normal vision were prospectively imaged using 1 of 2 commercial SD-OCT systems. For each eye, the entry position of the SD-OCT beam through the pupil was varied horizontally and vertically. The reflectivity of outer retinal layers was measured as a function of beam position, and thicknesses were recorded. RESULTS: The reflectivity of HFL was directionally dependent and increased with eccentricity on the side of the fovea opposite the entry position. When HFL was included in the measurement, the thickness of the outer nuclear layer (ONL) of central horizontal B-scans increased by an average of 52% in three subjects quantified. Four cases of pathology, in which alterations to the normal macular geometry affected HFL intensity, were identified. CONCLUSIONS: The authors demonstrated a novel method to distinguish HFL from true ONL. An accurate measurement of the ONL is critical to clinical studies measuring photoreceptor layer thickness using any SD-OCT system. Recognition of the optical properties of HFL can explain reflectivity changes imaged in this layer in association with macular pathology.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.10-5946
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Photoreceptor Cells, Vertebrate Cytology Presynaptic Terminals Retinal Ganglion Cells Tomography, Optical Coherence Prospective Studies Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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