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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Kai Sun, Jin Wang, Yongjun He, Yuan Gao, Kun He, Zhonggui |
| Description | Author Affiliation: Liu K ( Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China. hezhonggui@gmail.com) |
| Abstract | Two types of 10-hydroxycamptothecin (10-HCPT) loaded nanostructured lipid carriers (NLC-F 68 and NLC-Brij 35) intended for use as the alternative formulation of 10-HCPT for parenteral administration were prepared using an emulsification-ultrasonication method and fully characterized from physicochemical and in vitro release standpoint. The particle size was measured by laser diffraction, being 108 nm and 126 nm for NLC-F 68 and NLC-Brij 35, respectively. Zeta potentials of two NLCs were -28.5 mV and -32.1 mV analyzed by photon correlation spectroscopy. The incorporated efficiency was more than 85%. It is observed that NLCs are homogeneous and spherical in shape by transmission electron microscopy. Differential scanning calorimetry analysis of NLCs showed that 10-HCPT was dispersed within NLC in an amorphous state. The combination of trehalose and mannitol as cryoprotectant was most suitable for HCPT-NLC lyophilization. The in vitro release behavior for two types of NLC was similar and displayed biphasic drug release pattern with rapid release at the initial stage and prolonged release afterwards. These results suggest that NLC could be exploited as a carrier of 10-HCPT with high incorporation efficiency and controlled release and that NLC may serve as the alternative delivery system for parenteral administration of 10-HCPT. |
| File Format | HTM / HTML |
| ISSN | 03639045 |
| Issue Number | 5 |
| Volume Number | 34 |
| e-ISSN | 15205762 |
| Journal | Drug Development and Industrial Pharmacy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2008-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antineoplastic Agents, Phytogenic Chemistry Camptothecin Analogs & Derivatives Nanostructures Administration & Dosage Calorimetry, Differential Scanning Chromatography, High Pressure Liquid Delayed-action Preparations Drug Carriers Drug Compounding Freeze Drying Injections, Intravenous Lactones Microscopy, Electron, Transmission Particle Size Poloxamer Polyethylene Glycols Solubility Surface-active Agents Ultrasonics X-ray Diffraction Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
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