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Nanoencapsulation of a water soluble drug in biocompatible polyesters. Effect of polyesters melting point and glass transition temperature on drug release behavior.

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Nanoencapsulation of a water soluble drug in biocompatible polyesters. Effect of polyesters melting point and glass transition temperature on drug release behavior.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Karavelidis, Vassilios Giliopoulos, Dimitrios Karavas, Evangelos Bikiaris, Dimitrios
Description	Country affiliation: Greece Author Affiliation: Karavelidis V ( Laboratory of Organic Chemical Technology, Chemistry Department, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.)
Abstract	Five polyesters based on 1,3-propanediol or ethylene glycol and an aliphatic dicarboxylic acid were used for the preparation of Ropinirole HCl-loaded nanoparticles. The advantage of the present study is that the used polyesters - as well as poly(lactic acid) (PLA) - have similar degree of crystallinity but different melting points, varying from 46.7 to 166.4°C. Based on polymer toxicity on HUVEC, the biocompatibility of these aliphatic polyesters was found comparable to that of PLA and thus the studied polyesters could be used as drug carriers. Drug encapsulation in polyesters was performed via emulsification/solvent evaporation method. Particle size of drug-loaded nanoparticles was between 140 and 190 nm, as measured by light scattering. Drug loading content for all the polyesters varies between 10 and 16% and their entrapment efficiency is relatively high (32-48%). WAXD patterns of nanoparticles show that Ropinirole HCl lies in amorphous state within polymer matrices. Drug release diagrams reveal that the higher percentage of Ropinirole HCl is released during the first 6h after its insertion in the dissolution medium. Fast release rates of the drug are attributed to high hydrophilicity of Ropinirole HCl. Melting point (T(m)) and glass transition temperature (T(g)) of the host polymer matrices seem to be important parameters, since higher drug release rates are observed in polyesters with low T(m) and T(g).
File Format	HTM / HTML
ISSN	09280987
Issue Number	5
Volume Number	41
e-ISSN	18790720
Journal	European Journal of Pharmaceutical Sciences
Language	English
Publisher	Elsevier
Publisher Date	2010-12-23
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Chemistry Discipline Pharmacology Freezing Nanoparticles Chemistry Polyesters Biocompatible Materials Cells, Cultured Dopamine Agonists Administration & Dosage Drug Carriers Humans Hydrophobic And Hydrophilic Interactions Indoles Lactic Acid Particle Size Polyethylene Glycols Polymers Propylene Glycols Solubility Transition Temperature Water Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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