NDLI: Blood contrast agents enhance intrinsic signals in the retina: evidence for an underlying blood volume component.

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Blood contrast agents enhance intrinsic signals in the retina: evidence for an underlying blood volume component.

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Blood contrast agents enhance intrinsic signals in the retina: evidence for an underlying blood volume component.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schallek, Jesse Ts'o, Daniel
Description	Country affiliation: United States Author Affiliation: Schallek J ( Department of Neurosurgery, Upstate Medical University, Syracuse, New York, USA. schallej@upstate.edu)
Abstract	PURPOSE: To examine the extent to which neurovascular coupling contributes to stimulus-evoked intrinsic signals in the retina. METHODS: The retinas of five adult cats were examined in vivo. Animals were anesthetized and paralyzed for imaging stability. The retinas were imaged through a modified fundus camera capable of presenting patterned visual stimuli simultaneous with a diffuse near infrared (NIR). RESULTS: Injections of nigrosin increased signal strength by as much as 36.3%, and indocyanine green (ICG) increased signal magnitudes by as much as 38.1%. In both cases, intrinsic signals maintained a colocalized pattern of activation corresponding to the visual stimulus presented. The time course of the evoked signals remained unaltered. The spectral dependency of signal enhancement mirrored the absorption spectra of the injected dyes. CONCLUSIONS: The data are consistent with a neurovascular coupling effect in the retina. Patterned visual stimuli evoke colocalized NIR reflectance changes. The patterned decrease in reflectance was enhanced after nigrosin or ICG was injected into the systemic circulation. These findings suggest stimulus-evoked changes in blood volume underlie a component of the retinal intrinsic signals.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.10-5215
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aniline Compounds Administration & Dosage Blood Volume Physiology Coloring Agents Evoked Potentials, Visual Photic Stimulation Retina Animals Blood Circulation Contrast Media Electrophysiology Indocyanine Green Drug Effects Retinal Vessels Research Support, N.i.h., Extramural Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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