NDLI: The effect of ageing on in vivo human ciliary muscle morphology and contractility.

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How should we measure the ciliary muscle?

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The effect of ageing on in vivo human ciliary muscle morphology and contractility.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Davies, Leon N. Sheppard, Amy L.
Description	Country affiliation: United kingdom Author Affiliation: Sheppard AL ( Ophthalmic Research Group, Life and Health Sciences, Aston University, Birmingham, United Kingdom.)
Abstract	PURPOSE: To assess the effect of ageing on in vivo human ciliary muscle morphology and contractility during accommodation. METHODS: Seventy-nine subjects, aged 19-70 years were recruited. High-resolution images were acquired of nasal and temporal ciliary muscle in the relaxed state, and at stimulus vergence levels of -4 and -8 D, using anterior segment optical coherence tomography (AS-OCT). Objective refractions and axial lengths were also recorded. Linear regression analysis was performed to determine the effect of age on nasal and temporal ciliary muscle morphologic characteristics. RESULTS: Ciliary muscle anterior length decreased significantly with age both nasally (R = 0.461, P = 0.001) and temporally (R = 0.619, P < 0.001) in emmetropic eyes. In a subset of 37 participants, ciliary muscle maximum width increased significantly with age, by 2.8 µm/year nasally (R = 0.54, P < 0.001) and 3.0 µm/year temporally (R = 0.44, P = 0.007), while the distance from the inner apex of the ciliary muscle to the scleral spur decreased significantly with age on both the nasal and temporal aspects (R = 0.47; P = 0.004 and R = 0.43; P = 0.009, respectively). During accommodation, changes to ciliary muscle thickness and length remained constant throughout life. CONCLUSIONS: The human ciliary muscle undergoes age-dependent changes in morphology that suggest an antero-inwards displacement of muscle mass, particularly in emmetropic eyes. However, the morphologic changes observed appear not to affect the ability of the muscle to contract during accommodation, even in established presbyopes, thus supporting a lenticular model of presbyopia development.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-28
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Physiology Ciliary Body Muscle Contraction Muscle, Smooth Accommodation, Ocular Axial Length, Eye Biometry Emmetropia Presbyopia Physiopathology Refraction, Ocular Tomography, Optical Coherence Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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