NDLI: Outflow physiology of the mouse eye: pressure dependence and washout.

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Outflow physiology of the mouse eye: pressure dependence and washout.

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Outflow physiology of the mouse eye: pressure dependence and washout.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Boussommier-Calleja, Alexandra Stamer, W. Daniel Lei, Yuan Ethier, C. Ross Overby, Darryl R.
Description	Country affiliation: United kingdom Author Affiliation: Lei Y ( Department of Bioengineering, Imperial College London, London, United Kingdom.)
Abstract	PURPOSE: Mice are commonly used in glaucoma research, but relatively little is known about aqueous outflow dynamics in the species. To facilitate future use of the mouse as a model of aqueous humor outflow, several fundamental physiological parameters were measured in the mouse eye. METHODS: Eyes from adult mice of either sex (C57BL/6 background) were enucleated, cannulated with a 33-gauge needle, and perfused at constant pressure while inflow was continuously measured. RESULTS: At 8 mm Hg, total outflow facility (C(total)) was 0.022 ± 0.005 µL/min/mm Hg (all values mean ± SD; n = 21). The flow-pressure relationship was linear up to 35 mm Hg. The conventional outflow facility (C(conv)) was 0.0066 ± 0.0009 µL/min/mm Hg, and the unconventional outflow (F(u)) was 0.114 ± 0.019 µL/min, both measured at room temperature. At 8 mm Hg, 66% of the outflow was via the unconventional pathway. In a more than 2-hour-long perfusion at 8 mm Hg, the rate of facility change was 2.4% ± 5.4% (n = 11) of starting facility per hour. The ocular compliance (0.086 ± 0.017 µL/mm Hg; n = 5) was comparable to the compliance of the perfusion system (0.100 ± 0.004 µL/mm Hg). CONCLUSIONS: Mouse eyes are similar to human eyes, in that they have no detectable washout rate and a linear pressure-flow relationship over a broad range of intraocular pressures. Because of the absence of washout and the apparent presence of a true Schlemm's canal, the mouse is a useful model for studying the physiology of the inner wall of Schlemm's canal and the conventional outflow tissues.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.10-6019
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anterior Eye Segment Metabolism Aqueous Humor Secretion Blood-aqueous Barrier Physiology Intraocular Pressure Animals Compliance Mice Mice, Inbred C57bl Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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