NDLI: Morphometric characteristics of central retinal artery and vein endothelium in the normal human optic nerve head.

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Morphometric characteristics of central retinal artery and vein endothelium in the normal human optic nerve head.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cringle, Stephen J. Kang, Min H. Balaratnasingam, Chandrakumar Yu, Dao-Yi Morgan, William H. McAllister, Ian L. Yu, Paula K.
Description	Country affiliation: Australia Author Affiliation: Kang MH ( Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia.)
Abstract	PURPOSE: This study documents the morphometric features of arterial and venous endothelia in the different laminar regions of the normal human optic nerve head and speculates on the hemodynamic characteristics of the central retinal artery (CRA) and central retinal vein (CRV). METHODS: Twenty normal human eyes were used. Microcannulation techniques were used to label the cytoskeleton and nuclei of endothelial cells in the CRA and CRV, after which images were captured using confocal microscopy. Length, width, length-to-width ratio, and area measurements were obtained from endothelium and its nuclei. Nucleus position with respect to cell apex and direction of blood flow was also quantified. Comparisons were made between prelaminar, anterior lamina cribrosa, posterior lamina cribrosa, and retrolaminar regions. Venous and arterial endothelial cell morphology was also compared. RESULTS: There was significant variation in venous endothelial morphology across the different laminar regions; however, no differences were found in arterial endothelial characteristics (all P > 0.1065). Significant differences were found between arterial and venous endothelium in all laminar regions apart from the posterior lamina cribrosa, where only nuclear area (P = 0.0001) and nucleus position (P = 0.0088) were found to be different. CONCLUSIONS: Arterial-like appearance of venous endothelium in the posterior lamina cribrosa, where pressure gradient forces are predicted to be greatest and CRV luminal diameter is known to be narrowest, implicates this as a site of altered hemodynamic stress. Heterogeneity of venous endothelium may have relevance for understanding ocular vascular diseases such as central retinal vein occlusion.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	3
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-03-14
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Endothelium, Vascular Cytology Optic Disk Blood Supply Retinal Artery Retinal Vein Cell Nucleus Cell Size Hemodynamics Physiology Microscopy, Confocal Microscopy, Fluorescence Comparative Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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