NDLI: Characterization of Living Drosophila Embryos using Micro Robotic Manipulation System

Content Provider	IEEE Xplore Digital Library
Author	Shen, Y. Wejinya, U.C. Ning Xi Pomeroy, C.A. Yonghui Xue Zhun Fan
Copyright Year	2006
Description	Author affiliation: Dept. of Electr. & Comput. Eng., Michigan State Univ., East Lansing, MI (Shen, Y.; Wejinya, U.C.; Ning Xi; Pomeroy, C.A.; Yonghui Xue)
Abstract	This paper aims at investigating and characterizing force behavior and mechanical properties of living drosophila embryos using an in situ modeled PVDF (polyvinylidene fluoride) piezoelectric microforce sensing tool with a resolution in the range of sub-muN. Drosophila embryo is one of the most studied organisms in biological research, medical research, genetics and developmental biology, and has implications in the cure of human diseases. In order to achieve high efficiency and accuracy during microinjection of genetic material into a drosophila embryo, it is absolutely necessary to allow close monitoring of the magnitude and direction of microinjection forces acting on the embryo during injection. In this paper, a microrobotic biomanipulation platform integrating a two-axis (2-D) modeled PVDF micro-force sensor is used to implement force sensing during microinjection of living drosophila embryos. Micro injection forces and membrane deformation of embryos in different stages of embryogenesis are found. Ultimately, the technology will provide a critical and major step towards the development of automated biomanipuation for batch microinjection of living embryos in genetics
Starting Page	568
Ending Page	573
File Size	318687
Page Count	6
File Format	PDF
ISBN	1424402581
DOI	10.1109/IROS.2006.282385
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-09
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Embryo Microinjection Genetics Robot sensing systems Mechanical factors Biological system modeling Organisms Humans Diseases Biological materials
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in