NDLI: Locomotion and eye behaviour under controlled environment in individuals with Alzheimer's disease

Content Provider	IEEE Xplore Digital Library
Author	Suzuki, T. Keir Yong Biao Yang Carton, A. McCarthy, I. Papadosifos, N. Boampong, D. Holloway, C. Tyler, N. Crutch, S.
Copyright Year	2015
Description	Author affiliation: Dept. of Civil, Environ. & Geomatic Enginnering, Univ. Coll. London, London, UK (Suzuki, T.; Biao Yang; McCarthy, I.; Papadosifos, N.; Boampong, D.; Holloway, C.; Tyler, N.) \|\| Dementia Res. Centre, Univ. Coll. London, London, UK (Keir Yong; Carton, A.; Crutch, S.)
Abstract	This study aimed to examine simple locomotion and eye behaviour of individuals with Posterior Cortical Atrophy (PCA) and typical Alzheimer's disease (tAD) within a simulated real-world environment. Posterior cortical atrophy (PCA) is a neurodegenerative condition characterised by parietal, occipital and occipito-temporal tissue loss and progressive impairment of higher-order visual function in contrast to relatively spared memory and language. Targeted types of locomotion were walking in a series of corridors, up or down stairs, and across an open room with or without the presence of an obstacle. Eye tracking measures and inertial moment units (IMU) were used in this experiment, and resultant acceleration of left foot and fixation duration were extracted. Findings from three participants are presented as a case series: one control, one PCA and one tAD patient. The averaged resultant acceleration of PCA patient was the slowest in all types of locomotion, especially in stairs. The averaged resultant accelerations of PCA and tAD participants were slower than the control participant. The PCA participant had longer mean fixation durations than the tAD and control participants, however, mean fixation duration was similar between tAD and control participants. Results may help characterise locomotion and eye behaviour in PCA and tAD and may suggest ways to support effective diagnosis and assessment of disease progression.
Starting Page	6594
Ending Page	6597
File Size	796236
Page Count	4
File Format	PDF
ISSN	1557170X
e-ISBN	9781424492718
DOI	10.1109/EMBC.2015.7319904
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-08-25
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Principal component analysis Acceleration Foot Visualization Shape Atmospheric measurements Particle measurements
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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