NDLI: A mathematical model of the calcium transient in urinary bladder smooth muscle cells

Content Provider	IEEE Xplore Digital Library
Author	Dave, V. Mahapatra, C. Manchanda, R.
Copyright Year	2015
Description	Author affiliation: Dept. of Biosci. & Bioeng., Indian Inst. of Technol. Bombay, Mumbai, India (Dave, V.; Mahapatra, C.; Manchanda, R.)
Abstract	An increase in cytoplasmic calcium $(Ca^{2+})$ concentration $([Ca^{2+}]_{i})$ is a prerequisite for the contraction of detrusor smooth muscle (DSM) cells . The increase in $[Ca^{2+}]_{i}$ is accomplished by $Ca^{2+}$ entry mainly via voltage dependent L-type $Ca^{2+}$ channel and $Ca^{2+}$ release from intracellular stores. We report here a simulation of the processes that regulate intracellular $Ca^{2+}$ and their dependence on $Ca^{2+}$ concentration. Based on experimentally recorded data, mathematical equations for $Ca^{2+}$ current (generated mainly by L-type $Ca^{2+}$ channel) are developed along with representation of $Ca^{2+}ATPase$ pump currents. The plasma membrane $Ca^{2+}ATPase$ (PMCA) pump and sarco/endoplasmic reticulum $Ca^{2+}ATPase$ (SERCA) pump are responsible for lowering $[Ca^{2+}]_{i}$ which leads to relaxation of smooth muscle. Our model simulates $Ca^{2+}$ current, action potential and the $Ca^{2+}$ transient response so as to reasonably mimic the experimental recordings. In novel findings, currents produced by PMCA and SERCA along with their amplitude and waveform pattern under voltage clamp condition have been predicted for DSM cells. The model has further been used to produce the $Ca^{2+}$ transient which results because of L-type $Ca^{2+}$ channel, $Ca^{2+}$ release from intracellular store, PMCA, SERCA and presence of buffer in the cytoplasm. To explore the model further, $Ca^{2+}$ transient decay rate in control condition is compared to the decay rate reached when PMCA and SERCA are inhibited. We conclude that this model can be used to describe the $Ca^{2+}$ transient response produced by the DSM cell in response to depolarization of cell membrane.
Starting Page	5359
Ending Page	5362
File Size	2118066
Page Count	4
File Format	PDF
ISSN	1557170X
e-ISBN	9781424492718
DOI	10.1109/EMBC.2015.7319602
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-08-25
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Transient analysis Mathematical model Calcium Muscles Physiology Bladder Electric potential calcium transient urinary bladder L-type Ca²⁺ channel PMCA SERCA
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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