NDLI: Autonomic nervous system response to L-dopa in patients with advanced Parkinson's disease

Content Provider	IEEE Xplore Digital Library
Author	Ruonala, V. Tarvainen, M.P. Karjalainen, P.A. Pekkonen, E. Rissanen, S.M.
Copyright Year	2015
Description	Author affiliation: Dept. of Neurology, Helsinki Univ. Central Hosp., Helsinki, Finland (Pekkonen, E.) \|\| Dept. of Appl. Phys., Kuopio Univ. Hosp., Kuopio, Finland (Tarvainen, M.P.) \|\| Dept. of Appl. Phys., Univ. of Eastern Finland, Joensuu, Finland (Ruonala, V.; Karjalainen, P.A.; Rissanen, S.M.)
Abstract	Levodopa is the main treatment method for reducing the symptoms of Parkinson's disease. Whereas it reduces the motor symptoms efficiently, its effect on autonomous nervous system is not clear. The information about effect of levodopa on heart rate variability is not coherent between the studies. In this study, ECG of 11 patients with Parkinson's disease was measured during levodopa challenge with pronounced dose of fast release levodopa to ensure the positive drug effect for deep brain stimulation treatment. Heart rate variability analysis was done at three time points, before administration of levodopa, 30 and 60 minutes after administration. After 30 minutes of administration, the HRV parameters show that parasympathetic nervous system activity is decreased and the sympatho-vagal balance is shifted towards sympathetic control. At 60 minutes after administration the parasympathetic nervous system activates slightly and causes a decrease in heart rate.
Starting Page	6162
Ending Page	6165
File Size	663285
Page Count	4
File Format	PDF
ISSN	1557170X
e-ISBN	9781424492718
DOI	10.1109/EMBC.2015.7319799
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-08-25
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Heart rate variability Parkinson's disease Drugs Time measurement Nervous system Medical diagnostic imaging
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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