NDLI: Investigation of the composition of arterial plaques based on arterial waveforms and material properties

Content Provider	IEEE Xplore Digital Library
Author	Feng, J. Rajeswaran, T. He, S. Wilkinson, F.L. Serracino-Inglott, F. Azzawi, M. Parikh, V. Miraftab, M. Alexander, M.Y.
Copyright Year	2015
Description	Author affiliation: Fac. of Sci. & Eng., Manchester Metropolitan Univ., Manchester, UK (Feng, J.; Rajeswaran, T.; He, S.; Wilkinson, F.L.; Azzawi, M.; Alexander, M.Y.) \|\| Central Manchester Univ. Hosp., Manchester, UK (Serracino-Inglott, F.) \|\| Bolton Univ., Bolton, UK (Parikh, V.; Miraftab, M.)
Abstract	Stroke is mainly caused by a narrowing of the carotid artery from a build-up of plaque. The risk of plaque rupture and subsequent stroke is dependent on plaque composition. Advances in imaging modalities offer a non-invasive means to assess the health of blood vessels and detect damage. However, the current diagnosis fails to identify patients with soft lipid plaque that are more susceptible to fissure, resulting in stroke. The aim of this study was to use waveform analysis to identify plaque composition and the risk of rupture. We have investigated pressure and flow by combining an artificial blood flow circuit with tubing containing different materials, to simulate plaques in a blood vessel. We used fat and bone to model lipid and calcification respectively to determine if the composition of plaques can be identified by arterial waveforms. We demonstrate that the arterial plaque models with different percentages of calcification and fat, results in significantly different arterial waveforms. These findings imply that arterial waveform analysis has the potential for further development to identify the vulnerable plaques prone to rupture. These findings could have implications for improved patient prognosis by speed of detection and a more appropriate treatment strategy.
Starting Page	993
Ending Page	996
File Size	996807
Page Count	4
File Format	PDF
ISSN	1557170X
e-ISBN	9781424492718
DOI	10.1109/EMBC.2015.7318531
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-08-25
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Bones Testing Sealing materials Blood vessels Biomedical imaging Atherosclerosis Electron tubes
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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