NDLI: Controlled thermal-sensitive liposomes release on a disposable microfluidic device

Content Provider	IEEE Xplore Digital Library
Author	Long Meng Zhiting Deng Lili Niu Feiyan Cai Hairong Zheng
Copyright Year	2015
Description	Author affiliation: Paul C. Lauterbur Res. Center for Biomed. Imaging, Shenzhen Inst. of Adv. Technol., Shenzhen, China (Long Meng; Zhiting Deng; Lili Niu; Feiyan Cai; Hairong Zheng)
Abstract	High intensity focused ultrasound (HIFU) triggered drug release as one of promising approaches for local drug delivery is gaining more attention as ultrasound allows the deposition of the thermal and mechanical energies to a specific localized region in a noninvasive manner. Release of encapsulated drugs from a nano-carrier such as liposome could further achieve a higher local drug concentration and reduce the toxicity effects under the stimulus of temperature elevation. This paper presents a micro HIFU (MHIFU) microfluidic device to enable mimic the bulky HIFU transmission system without the need of high power consumption and control the release of low temperature-sensitive liposomes (LTSL). Moreover, by adjusting the input signal, the temperature can be elevated and maintained at 37°C, 42°C and 50°C precisely with the error of ±0.3°C. The flow cytometry results show that HIFU-mediated drug delivery lead to an increase in uptake compared to water incubation-induced drug release at 42°C. Microfluidic technology may offer a promising alternative method for investigation of the complex dynamics between ultrasound and organisms in an ultramicroscopic manner.
Starting Page	5912
Ending Page	5915
File Size	803022
Page Count	4
File Format	PDF
ISSN	1557170X
e-ISBN	9781424492718
DOI	10.1109/EMBC.2015.7319737
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-08-25
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Temperature measurement Acoustics Temperature sensors Fluorescence Fluids Ultrasonic imaging
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Non-invasive measurement of the temperature rise in tissue surrounding a kidney stone subjected to ultrasonic propulsion

Measurement of ultrasonic diaphragmatic motion

Algorithm for an implantable fluorescence based glucose sensor

Developing a thermoacoustic sensor adaptive to ambient temperatures

The use of sonication treatment to completely decellularize blood arteries: A pilot study

Ambulatory measurement of foot kinematics using wearable ultrasonic sensors

Young's modulus measurement on pig trachea and bronchial airways

Ultrasonic beamforming system for interrogating multiple implantable sensors

Virtual Thermistor

Controlled thermal-sensitive liposomes release on a disposable microfluidic device

Similar Documents

Non-invasive measurement of the temperature rise in tissue surrounding a kidney stone subjected to ultrasonic propulsion

Measurement of ultrasonic diaphragmatic motion

Algorithm for an implantable fluorescence based glucose sensor

Developing a thermoacoustic sensor adaptive to ambient temperatures

The use of sonication treatment to completely decellularize blood arteries: A pilot study

Ambulatory measurement of foot kinematics using wearable ultrasonic sensors

Young's modulus measurement on pig trachea and bronchial airways

Ultrasonic beamforming system for interrogating multiple implantable sensors

Virtual Thermistor

Controlled thermal-sensitive liposomes release on a disposable microfluidic device