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Content Provider | IEEE Xplore Digital Library |
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Author | Ai-Hua Wang Guang-Hao Zhang Cheng Zhang Xiao-Lin Huo Tao Song |
Copyright Year | 2015 |
Description | Author affiliation: Beijing Key Lab. of Bioelectromagnetism, Inst. of Electr. Eng., Beijing, China (Ai-Hua Wang; Guang-Hao Zhang; Cheng Zhang; Xiao-Lin Huo; Tao Song) |
Abstract | The effect of applied electric field on neuroprotection and axonal regeneration has been studied in previous studies of acute spinal cord injury (SCI). However, due to the complexity of the microenvironment of the lesion site, the underlying mechanism of applied electric field is not yet fully understood. Thus, the injury potential, a significant index of the microenvironment change, was investigated in ex vivo spinal cords compression injury. Spinal cords isolated from rat were cultured in a double sucrose gap recording chamber. Both compound action potential (CAP) and injury potential were measured. Compression induced the decreasement of compound action potential, but the amplitude of CAP increased gradually after decompression. Compression also lead to the appearance of injury potential, represented by the voltage difference between the gap potential before and after compression, and the injury potential decreased with time logarithmicly after decompression. Intracellular $Na^{+}$ and $Ca^{2+}$ concentrations were measured and results showed that after injury these ions flowed into intracellular space. Therefore, the current approach can provide a basis for investigating the formation mechanism of the injury potential and help understand the pathophysiology of the SCI. |
Starting Page | 4659 |
Ending Page | 4662 |
File Size | 789903 |
Page Count | 4 |
File Format | |
ISSN | 1557170X |
e-ISBN | 9781424492718 |
DOI | 10.1109/EMBC.2015.7319433 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 2015-08-25 |
Publisher Place | Italy |
Access Restriction | Subscribed |
Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Subject Keyword | Injuries Electric potential Spinal cord injury Sugar Compounds Biomedical monitoring |
Content Type | Text |
Resource Type | Article |
Subject | Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition |
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