NDLI: Magnetically induced deep brain stimulation of neuronal firing for pain relief

Content Provider	IEEE Xplore Digital Library
Author	Fan Jie Wu Tiecheng Lee Kim Seng Lee Xiaoping Li
Copyright Year	2012
Description	Author affiliation: Nat. Univ. of Singapore, Singapore, Singapore (Fan Jie; Wu Tiecheng; Lee Kim Seng; Lee Xiaoping Li)
Abstract	Pain, either acute pain or chronic pain, is usually treated/relieved by chemical means, in which nociceptive signals are blocked from transmitting into the pain registration sites in the brain. However, besides their side effects, chemical means of pain relief are not always effective, causing some serious clinical incidents like anesthesia awareness and chronic pains that are not treatable. A physical means of pain relief that physically modifies pain perception at the brain sites responsible for pain registration could be more effective, for both acute pain and chronic pain. In this paper a novel approach of magnetically induced deep brain modulation of neuronal firing is proposed for pain treatment/relief, in which pain treatment/relief is bioelectronics based and is non-invasive and free of side effects. A novel pulse magnetic field projector has been developed for pain relief through modulation of neuronal firing at the anterior cingulate cortex (ACC). It is based on the neuroscience findings that pain registration in the brain is closely related to the excitation of nociceptive neurons at the ACC, in which the nociceptive neuronal firing rate increases as pain gets more intense. The mechanism of pain relief in the proposed approach is to modify the nociceptive neuronal firing rate at the ACC by magnetically inducing a pulse electric field applying on the neurons in the ACC, hyperpolarizing the neurons that are firing at high frequency during pain perception, resulting in a low level firing rate associated to no pain. A parametric study has been carried out to determine the physical and technical parameters of the proposed approach. The feasibility of the approach has been verified by simulation with the modulation implemented on a reconstructed ACC LV pyramidal cell using Hodgkin-Huxley style model. Action potentials recorded in the soma indicated that the firing frequency can be modulated by the applied pulse electric field.
Sponsorship	IEEE Eng. Medicine Biol. Soc.
Starting Page	731
Ending Page	734
File Size	436946
Page Count	4
File Format	PDF
ISBN	9781424441198
ISSN	1557170X
e-ISBN	9781457717871
DOI	10.1109/EMBC.2012.6346035
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-28
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Pain Neurons Firing Electric fields Magnetic fields Electric potential Modulation
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Rational modulation of neuronal processing with applied electric fields

Study on performance evaluation system for transcranial magnetic stimulation devices

Coil design considerations for deep-brain transcranial magnetic stimulation (dTMS)

Modelling of deep transcranial magnetic stimulation: Different coil configurations

Addition of deep brain stimulation signal to a local field potential driven Izhikevich model masks the pathological firing pattern of an STN neuron

Approximating transcranial magnetic stimulation with electric stimulation in mouse: A simulation study

Electroconvulsive therapy in the presence of deep brain stimulation implants: Electric field effects

Micro vs macro electrode DBS stimulation: A dosimetric study

The potential of multilateral analyses of neuronal activities in future brain-machine interface research

Magnetically induced deep brain stimulation of neuronal firing for pain relief

Similar Documents

Rational modulation of neuronal processing with applied electric fields

Study on performance evaluation system for transcranial magnetic stimulation devices

Coil design considerations for deep-brain transcranial magnetic stimulation (dTMS)

Modelling of deep transcranial magnetic stimulation: Different coil configurations

Addition of deep brain stimulation signal to a local field potential driven Izhikevich model masks the pathological firing pattern of an STN neuron

Approximating transcranial magnetic stimulation with electric stimulation in mouse: A simulation study

Electroconvulsive therapy in the presence of deep brain stimulation implants: Electric field effects

Micro vs macro electrode DBS stimulation: A dosimetric study

The potential of multilateral analyses of neuronal activities in future brain-machine interface research

Magnetically induced deep brain stimulation of neuronal firing for pain relief