NDLI: Relationship between marrow perfusion and bone mineral density: A pharmacokinetic study of DCE-MRI

Content Provider	IEEE Xplore Digital Library
Author	Ma, H.T. Griffith, J.F. Xinxin Zhao Haiyan Lv Yeung, D.K.W. Ping-Chung Leung
Copyright Year	2012
Description	Author affiliation: Dept. of Electron. & Inf. Eng., Harbin Inst. of Technol., Shenzhen, China (Ma, H.T.; Xinxin Zhao; Haiyan Lv) \|\| Jockey Club Centre for Osteoporosis Care & Control, Chinese Univ. of Hong Kong, Hong Kong, China (Ping-Chung Leung) \|\| Dept. of Diagnostic Radiol. & Organ Imaging, Chinese Univ. of Hong Kong, Hong Kong, China (Griffith, J.F.; Yeung, D.K.W.)
Abstract	A reduced bone perfusion has been found for osteoporotic subjects in previous studies. However, the physiological changes underlying the varied perfusion function is not well known yet. Tofts model is one of the most frequently used pharmacokinetic models in analyzing perfusion process. This study modified the Tofts model by replacing the arterial input function (AIF) by a new algorithm. The modified model was then employed to analyze vertebral bone marrow perfusion in subjects with different bone mineral density (BMD). Eighty-two male subjects were involved in this study and classified into three groups (normal, osteopenia, and osteoporosis) according to T-score. BMD was measured by dual-energy X-ray absorptiometry (DXA). The quantitative parameters derived from the pharmacokinetic model, $K^{trans}$ (extravasation transfer efficiency for blood perfusion) and $v_{e}$ (extravascular extracellular space for blood perfusion), showed a significant reduction in subjects with lower BMD, respectively. The results suggested that with the bone mineral content lost, the vascular wall properties as well as the bone marrow content may also vary. The resultant perfusion change may also influence the bone nutrition supply in reverse.
Sponsorship	IEEE Eng. Medicine Biol. Soc.
Starting Page	377
Ending Page	379
File Size	597692
Page Count	3
File Format	PDF
ISBN	9781424441198
ISSN	1557170X
e-ISBN	9781457717871
DOI	10.1109/EMBC.2012.6345947
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-28
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Bones Minerals Osteoporosis Imaging Analytical models Blood Mathematical model
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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