NDLI: Brain-friendly amperometric enzyme biosensor based on encapsulated oxygen generating biomaterial

Content Provider	IEEE Xplore Digital Library
Author	Chunyan Li Zhizhen Wu Hartings, J.A. Rajan, N. Chahine, N. Cheyuo, C. Ping Wang Pei-Ming Wu Golanov, E.V. Ahn, C.H. Narayan, R.K.
Copyright Year	2012
Description	Author affiliation: Microsyst. & BioMEMS Lab., Univ. of Cincinnati, Cincinnati, OH, USA (Zhizhen Wu; Ahn, C.H.) \|\| Biomech. & Bioeng. Res. Lab., Feinstein Inst. for Med. Res., Manhasset, NY, USA (Rajan, N.; Chahine, N.) \|\| Dept. of Neurosurg., Univ. of Cincinnati, Cincinnati, OH, USA (Hartings, J.A.) \|\| Cushing Neuromonitoroing Lab., Feinstein Inst. for Med. Res., Manhasset, NY, USA (Chunyan Li; Pei-Ming Wu; Golanov, E.V.; Narayan, R.K.) \|\| Dept. of Surg., Feinstein Inst. for Med. Res., Manhasset, NY, USA (Cheyuo, C.; Ping Wang)
Abstract	A novel first-generation Clark-type biosensor platform that can eliminate the oxygen dependence has been presented. Sufficient oxygen to drive the enzymatic reaction under hypoxic conditions was produced by encapsulated oxygen generating biomaterial, calcium peroxide. The catalase immobilized in chitosan matrix was coated on top of the groove to decompose residual hydrogen peroxide to oxygen. A glucose biosensor was developed on the proposed platform as proof of concept. Under hypoxic conditions, developed glucose biosensors maintained their sensitivity response around 84% of their response at oxygen tension of 151mmHg. The sensitivity deviation was less than 5.3% with the oxygen tension traversed from 0 to 57 mmHg. Under oxygen tension of 8.3mmHg, the sensitivity of 37.130nA/mM and the linear coefficient of $R^{2}=0.9968$ were obtained with the glucose concentration varying from 0.05 to 10mM. This new platform is particularly attractive for injured brain monitoring.
Sponsorship	IEEE Eng. Medicine Biol. Soc.
Starting Page	6003
Ending Page	6006
File Size	867219
Page Count	4
File Format	PDF
ISBN	9781424441198
ISSN	1557170X
e-ISBN	9781457717871
DOI	10.1109/EMBC.2012.6347362
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-28
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biosensors Sugar Electrodes Sensitivity USA Councils Biochemistry Calcium
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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