NDLI: Dissolution of magnetically marked tablets: Investigations in a physical phantom

Content Provider	IEEE Xplore Digital Library
Author	Biller, S. Domey, J. Fiedler, P. Holzhey, R. Richert, H. Haueisen, J.
Copyright Year	2012
Description	Author affiliation: Inst. of Biomed. Eng. & Inf., Ilmenau Univ. of Technol., Ilmenau, Germany (Biller, S.; Domey, J.; Fiedler, P.; Haueisen, J.) \|\| Innovent e.V., Jena, Germany (Holzhey, R.) \|\| Matesy GmbH, Jena, Germany (Richert, H.)
Abstract	Pharmacological research is strongly driven by maximizing the bioavailability of new pharmaceuticals. For orally applied drugs the bioavailability highly depends on the process of dissolution in the gastrointestinal tract and is affected by numerous physiological and environmental factors. Available techniques for in vivo monitoring of the dissolution process are very limited and not applicable for large studies. The technique of magnetic marker monitoring provides new prospects for these investigations. However, it is currently limited due to low fields common magnetic markers produce. Hence, only highly sensitive sensors are applicable. In this paper, we performed dissolution tests of novel markers in a physical phantom with magnetoresistive sensors in an unshielded environment. The markers were continuously localized and the movement through the phantom was tracked. By analyzing the changing magnetic moment of the markers we were able to monitor the progress of dissolution in the phantom. We conclude that our proposed phantom and tracking technique is an important step towards new systems for in vivo monitoring of pharmaceutical dissolution processes.
Sponsorship	IEEE Eng. Medicine Biol. Soc.
Starting Page	2072
Ending Page	2075
File Size	1525878
Page Count	4
File Format	PDF
ISBN	9781424441198
ISSN	1557170X
e-ISBN	9781457717871
DOI	10.1109/EMBC.2012.6346367
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-28
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Phantoms Magnetic field measurement Pharmaceuticals Magnetic noise Magnetic shielding Superconducting magnets Sensors
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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