NDLI: Coronary arterial stiffness is related with a loss of fractal complexity in the aortic pressure

Content Provider	IEEE Xplore Digital Library
Author	Cymberknop, L.J. Legnani, W. Pessana, F.M. Crottogini, A. Armentano, R.L.
Copyright Year	2012
Description	Author affiliation: Buenos Aires Regional Fac., Nat. Technol. Univ., Buenos Aires, Argentina (Cymberknop, L.J.; Legnani, W.; Pessana, F.M.; Armentano, R.L.) \|\| Fac. of Eng. & Exact & Natural Sci., Favaloro Univ., Buenos Aires, Argentina (Crottogini, A.)
Abstract	Arterial stiffening is a common but highly variable disorder. Additionally, excessive arterial pulsatility is associated with various common diseases of aging and hypertension. Fractal dimension (FD) quantifies the time series complexity defined by its geometrical representation. Objective: Arterial pressure and diameter time series were evaluated in order to assess the relationship between arterial stiffness and FD. Methods: Three Corriedale male sheep were operated. Left anterior descending artery (LAD) was dissected and the external arterial diameter was measured trough sonomicrometry. Similarly, a pressure microtransducer was positioned in the upper third of the ascending aorta. Simultaneous pressure and diameter were measured in normal state and under smooth muscle activation. Each time series FD were assessed by the application of Higuchi's method while arterial wall elastic modulus was evaluated by means of the pressure-strain relationship. Results: Coronary stiffness was increased from normal state to phenylephrine state (47.32%, 21.12%, 10.87%) while aortic pressure FD was decreased (2.11%, 2.57%, 6.85%), respectively. Conclusion: Acute hypertension induced by phenylephrine produces an increase in the coronary wall elastic modulus with a concomitant decrease in the fractal nature of the aortic pressure, suggesting that coronary stiffening is associated with an unwrinkled aortic pressure.
Sponsorship	IEEE Eng. Medicine Biol. Soc.
Starting Page	4200
Ending Page	4203
File Size	690813
Page Count	4
File Format	PDF
ISBN	9781424441198
ISSN	1557170X
e-ISBN	9781457717871
DOI	10.1109/EMBC.2012.6346893
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-28
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Fractals Time series analysis Blood pressure Pressure measurement Complexity theory Arteries Hypertension coronary arterial stiffness coronary artery fractal dimension unwrinkling
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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