NDLI: On the role of electric field orientation in optimal design of transcranial current stimulation

Content Provider	IEEE Xplore Digital Library
Author	Dmochowski, J.P. Bikson, M. Datta, A. Richardson, J. Fridriksson, J. Parra, L.C.
Copyright Year	2012
Description	Author affiliation: Univ. of South Carolina, Columbia, SC, USA (Richardson, J.; Fridriksson, J.) \|\| City Coll. of New York, New York, NY, USA (Dmochowski, J.P.; Bikson, M.; Parra, L.C.) \|\| Soterix Med., New York, NY, USA (Datta, A.)
Abstract	Transcranial current stimulation (tCS) is a promising noninvasive technique to elicit neuromodulation by passing weak electrical currents through scalp electrodes. While significant effort has been devoted towards designing stimulation protocols which “steer” current to regions of interest, previous work has been almost exclusively focused on the magnitude of the electric field, while ignoring the effects of direction. This is despite previous in vitro studies demonstrating that the angle between the field orientation and the cell axis of symmetry has significant effects on the resulting membrane polarization presumably underlying therapeutic effects. To that end, here we examine the impact of the desired electric field orientation on the optimal placement of electrodes for a given target region. Based on high-resolution head models derived from magnetic resonance scans of patients enrolled in a clinical trial examining the use of tCS in rehabilitation after stroke, we derive and employ an optimization algorithm which computes the montage maximizing directed current flow at the target. The results reveal a strong dependence of the optimal montage on the desired orientation; moreover, the magnitude of the induced electric field at the target region varies widely with the preferred direction. This suggests that identifying the desired electric field orientation at the region of interest is a crucial step in the development of rational electrical stimulation paradigms.
Sponsorship	IEEE Eng. Medicine Biol. Soc.
Starting Page	6426
Ending Page	6429
File Size	999706
Page Count	4
File Format	PDF
ISBN	9781424441198
ISSN	1557170X
e-ISBN	9781457717871
DOI	10.1109/EMBC.2012.6347465
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-28
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Anodes Optimization Cathodes Vectors Clinical trials Scalp
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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