NDLI: Carotid IMT variability (IMTV): Its design and validation in symptomatic vs. asymptomatic 142 Italian population

Content Provider	IEEE Xplore Digital Library
Author	Molinari, F. Meiburger, K.M. Saba, L. Ledda, G. Anzidei, M. Acharya, U.R. Guang Zeng Shafique, S. Nicolaides, A. Suri, J.
Copyright Year	2012
Description	Author affiliation: Vascular Diagostic Center, Nicosia, Cyprus (Nicolaides, A.) \|\| AtheroPoint LLC, CA, USA (Suri, J.) \|\| Dept. of Electron. & Telecommun., Politec. di Torino, Turin, Italy (Molinari, F.; Meiburger, K.M.) \|\| Dept. of Radiol., A.U.O. Cagliari, Cagliari, Italy (Saba, L.; Ledda, G.; Anzidei, M.) \|\| Dept. ECE, Ngee Ann Polytech., Singapore, Singapore (Acharya, U.R.) \|\| Mayo Clinic, Rochester, MN, USA (Guang Zeng)
Abstract	The carotid intima-media thickness (IMT) is a validated marker of cerebrovascular disease risk. This work presents a new parameter, the IMT variability (IMTV), and compares the IMT and IMTV in symptomatic and asymptomatic Italian patients. 142 patients were analyzed (age 59±11.2 years, 59% males), 42 of which suffered from TIA (transient ischemic attack) or minor stroke. The lumen-intima (LI) and media-adventitia (MA) interfaces were manually traced by a Reader, and automatically traced by an automated system (AutoEdge). These interfaces were then used to measure the IMT and IMTV along the carotid wall. Wilcoxon and Pearson correlation analyses were performed. There was about a 65% correlation between the manual and automated measurements of IMT. There was no statistical difference between the manual and automated IMTV measurements (Wilcoxon signed rank, p>;0.7). The observed mean IMT for symptomatic patients (0.83±0.44 mm for Reader vs. 0.82±0.35 mm for AutoEdge) was higher compared to asymptomatic patients (0.78±0.45 mm for Reader vs. 0.74±0.30 mm for AutoEdge). The symptomatic IMTV was about 11% higher than the asymptomatic IMTV when using Reader tracings and 8% higher when using AutoEdge. AutoEdge was very accurate in measuring the IMT and IMTV both for symptomatic and asymptomatic patients. Results showed that the symptomatic subjects had comparable IMT with respect to asymptomatic subjects, but a higher IMTV value.
Sponsorship	IEEE Eng. Medicine Biol. Soc.
Starting Page	2668
Ending Page	2671
File Size	460262
Page Count	4
File Format	PDF
ISBN	9781424441198
ISSN	1557170X
e-ISBN	9781457717871
DOI	10.1109/EMBC.2012.6346513
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-28
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Ultrasonic variables measurement Manuals Carotid arteries Atherosclerosis Biomedical measurements
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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