NDLI: Patterned Optical Activation of Retinal Ganglion Cells

Content Provider	IEEE Xplore Digital Library
Author	Farah, N. Reutsky, I. Shoham, S.
Copyright Year	2007
Description	Author affiliation: Technion - Israel Inst. of Technol., Haifa (Farah, N.; Reutsky, I.; Shoham, S.)
Abstract	Neuroprosthetic retinal interfaces depend upon the ability to bypass the damaged photoreceptor layer and directly activate populations of retinal ganglion cells (RGCs). To date, the preferred approach to this task largely relies on electrode array implants. We are currently pursuing two alternative methods for light-based direct activation of the RGCs. The first method is based on applying caged glutamate over the retina and uncaging it locally to obtain RGC excitation. The second method is to artificially cause RGCs to express Channelrhodopsin II (ChR2), a light-gated cation channel. In addition to being non-contact, optical techniques lend themselves relatively easily to a variety of technologies for achieving patterned stimulation with high temporal and spatial resolution. Using the Texas Instruments Digital Light Processing (DLP - DMD) technology, we have developed an optical stimulation system capable of controlled, large-scale, flexible stimulation of the retinal tissue with high temporal accuracy. In preliminary studies, we are performing patterned photo-stimulation experiments using samples of caged fluorescent probes and in rat retinas that were virally transfected with ChR2.
Starting Page	6368
Ending Page	6370
File Size	788439
Page Count	3
File Format	PDF
ISBN	9781424407873
ISSN	1557170X
DOI	10.1109/IEMBS.2007.4353812
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-08-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Retina Stimulated emission Neural prosthesis Photoreceptors Electrodes Implants Spatial resolution Instruments Optical control Lighting control
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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