NDLI: An Approach to the Assessment of Diabetic Neuropathy Based on Dynamic Pupillometry

Content Provider	IEEE Xplore Digital Library
Author	Ferrari, G.L. Marques, J.L.B. Gandhi, R.A. Emery, C.J. Tesfaye, S. Heller, S.R. Schneider, F.K. Gamba, H.R.
Copyright Year	2007
Description	Author affiliation: Fed. Univ. of Technol.-Parana, Curitiba (Ferrari, G.L.)
Abstract	Autonomic neuropathy (AN) is a common and serious complication of diabetes. Early detection is essential to enable appropriate interventional therapy. It has long been recognized that subjects with diabetic peripheral neuropathy (DPN) are at much greater risk of developing AN, but there is currently no simple screening tool to assess them. The aim of this study was to investigate pupil responsiveness in diabetic subjects with and without DPN using dynamic pupillometry. During the first test, one flash was administered and the pupil response recorded for 3 seconds. In the second test, twenty-five flashes at one-second intervals were administered and the pupil response recorded for 30 seconds. Several time related parameters were computed from the results. A total of 29 diabetic subjects (17 no DPN, 12 DPN) and 25 healthy volunteers took part in the study. In the first test, pupil-iris ratios in darkness, large deviation and plateau were significantly different between groups. Latency time from flash exposure to the start of constriction was significantly longer in diabetic subjects with DPN compared to healthy volunteers. There was no difference in latency times of largest deviation, plateau or duration of constriction between groups. In the second test, the pupil-iris ratios evaluated in the frame preceding the tenth and the twenty-fifth light flash were significantly greater in healthy volunteers than diabetic subjects with DPN. Latency time from the tenth and twenty-fifth flash exposure to the start of constriction was significantly shorter in healthy volunteers than in diabetic subjects with DPN. Our results show that diabetic subjects with DPN have sympathetic and parasympathetic dysfunction evidenced by diminished amplitude reflexes and significant smaller pupil diameter. Dynamic pupillometry may provide a simple, inexpensive and non-invasive tool to screen high-risk diabetic patients for diabetic autonomic neuropathy.
Starting Page	557
Ending Page	560
File Size	342702
Page Count	4
File Format	PDF
ISBN	9781424407873
ISSN	1557170X
DOI	10.1109/IEMBS.2007.4352351
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-08-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Diabetes Delay Testing Muscles Iris Size control Cardiology Parasympathetic nervous system Sympathetic nervous system Optical attenuators
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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