NDLI: Investigating the Coupling between Stimulation and Neural Activity: a Dynamic Modeling Approach

Content Provider	IEEE Xplore Digital Library
Author	Lefebvre, V.A. Ying Zheng Devonshire, I.M. Martin, C.J. Mayhew, J.E.W.
Copyright Year	2007
Description	Author affiliation: Univ. of Sheffield, Sheffield (Lefebvre, V.A.; Ying Zheng; Devonshire, I.M.; Martin, C.J.; Mayhew, J.E.W.)
Abstract	The objective of the present study was to build a dynamic model relating changes in neural responses in rat barrel cortex to an electrical whisker stimulation pulse train of varying frequencies. This work is part of a formal mathematical system currently being developed (e.g. [1] and [2]), which links stimulation to the blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal. Neural responses were measured in terms of local field potentials, which were then converted into current source density (CSD) data. Responses were found to be strongly suppressed immediately following the first stimulus pulse, before recovering to a steady state, which was maintained throughout the rest of the stimulation. The amplitude of this steady state decreases as the stimulation frequency increases, as shown in [3]-[6]. The model structure is based on the physiological pathway from the rat sensory organ to the cortex. Dynamic linear second order systems are used to model the excitatory as well as the suppressive components of the neural response. The interactions between components contain nonlinear modulations. The model was evaluated against CSD data from experiments with varying stimulation frequency (1-40 Hz), and shows a plausible fit. The model parameters obtained by optimization for different physiological conditions (anaesthetized or awake) were significantly different. Although this is a descriptive model, it may well have some physiological implications.
Starting Page	1105
Ending Page	1108
File Size	600702
Page Count	4
File Format	PDF
ISBN	9781424407873
ISSN	1557170X
DOI	10.1109/IEMBS.2007.4352489
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-08-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Joining processes Brain modeling Nonlinear dynamical systems Frequency Blood Hemodynamics Magnetic resonance imaging Steady-state Convolution State estimation
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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