NDLI: The Role of Intracarotid Cold Saline Infusion on a Theoretical Brain Model Incorporating the Circle of Willis and Cerebral Venous Return

Content Provider	IEEE Xplore Digital Library
Author	Neimark, M.A. Konstas, A.-A. Choi, J.H. Laine, A.F. Pile-Spellman, J.
Copyright Year	2007
Description	Author affiliation: Columbia Univ., New York (Neimark, M.A.)
Abstract	This study describes a theoretical model of brain cooling by intracarotid cold saline infusion which takes into account redistribution of cold perfusate through the circle of Willis (CoW) and cold venous return (VR) from the head. This model is developed in spherical coordinates on a four tissue layer hemispherical geometrical configuration. Temperature evolution is modeled according to the Pennes bioheat transfer equation. Simulations were run over a 1 hour period and 30 ml/min of freezing cold saline with the baseline model (no VR, no CoW), VR model (without CoW), and CoW model (with VR). The VR model demonstrates continuing temperature drop in the treatment region of the brain not observed in the baseline model and its final mean ipsilateral anterior temperature was approximately 31 degC. The temperature effect in the CoW model was present but less robust in the ipsilateral anterior region, as final temperature was 32 degC. However, cooling was also achieved in contralateral and posterior brain regions. This model continues to demonstrate the feasibility of intracarotid cold saline infusion for ischemic stroke therapy.
Starting Page	1140
Ending Page	1143
File Size	352780
Page Count	4
File Format	PDF
ISBN	9781424407873
ISSN	1557170X
DOI	10.1109/IEMBS.2007.4352497
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-08-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Brain modeling Cooling Temperature Virtual reality Arteries Blood Catheters Solid modeling Equations Robustness
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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